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A Study of Body Fat Distribution and Airway Mechanics in Healthy Adults
Sponsor: Maurizio F. Cereda, MD
Summary
This study investigates how body fat distribution affects airway closure and lung mechanics in healthy adults. Using Electrical Impedance Tomography (EIT), esophageal manometry, and computed tomography (CT), we aim to characterize how varying BMI and fat topography influence regional ventilation and airway collapse in supine and prone positions. Healthy volunteers with a range of BMIs will undergo a 2-hour imaging session with noninvasive and minimally invasive monitoring.
Official title: Imaging the Respiratory Effects of Truncal Adiposity in Healthy Subjects
Key Details
Gender
All
Age Range
18 Years - 80 Years
Study Type
INTERVENTIONAL
Enrollment
20
Start Date
2028-01-01
Completion Date
2030-06-30
Last Updated
2025-06-18
Healthy Volunteers
Yes
Conditions
Interventions
Body positioning
Each subject will breathe in both the supine and prone positions, randomly applied for 15 minutes each. The procedure will be performed twice: once for the assessment of respiratory physiology, and once for computed tomography acquisition.