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Stable Isotopes- Adults With Obesity
Sponsor: University of Illinois at Urbana-Champaign
Summary
In a crossover design, 8 participants will receive caloric drinks containing stable isotopes. In one arm of the study, participants will consume 6 hourly drinks containing two stable isotopes. Repeated blood, breath, urine, and muscle biopsies will be taken. In the second arm, participants will consume 1 drink containing 75g glucose, labeled with two stable isotopes of glucose. Periodic blood and breath will be taken over three hours.
Official title: Assessing Metabolic Health With Stable Isotope Tracer Techniques in Adults With Obesity
Key Details
Gender
All
Age Range
19 Years - 59 Years
Study Type
INTERVENTIONAL
Enrollment
8
Start Date
2025-09-12
Completion Date
2026-12-31
Last Updated
2025-10-07
Healthy Volunteers
Yes
Interventions
Indispensable Amino Acid Oxidation
Participants will ingest six hourly meals designed to provide 50% of the daily intake of 1.1 g·kgLBM. Additional energy (1.5x daily resting metabolic rate), carbohydrate (55%), and fat (35%) will be provided in beverages and protein-free cookies (for palatability). The first drink will contain priming doses of NaH13CO2 (0.176 mg·kg-1), \[13C\]phenylalanine (1.86 mg·kg-1), \[2H5\]phenylalanine (0.34 mg·kg-1) with all subsequent drinks containing 1.2 mg·kg-1 \[13C\]phenylalanine and 0.51 mg·kg-1 \[2H5\]phenylalanine.
Stable Isotope Oral Glucose Tolerance Test
Participants will consume a 75g glucose drink dissolved in 250 ml of water enriched with \[6,6\_2H2\]glucose and \[13C6\]glucose.
Locations (1)
Freer Hall - University of Illinois
Urbana, Illinois, United States