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Dose Escalated Concomitant Boost Radiotherapy for Early Breast Cancer
Sponsor: Fondazione Policlinico Universitario Campus Bio-Medico
Summary
The goal of this prospective, single-arm, phase II, non-randomized trial is to evaluate an hypofractionation schedule with high dose simultaneous integrated tumor bed boost in early breast cancer patients. The main question\[s\] it aims to answer are: * evaluate the rate of all grades of radiation-induced fibrosis at 4 years. * evaluate poor/fair cosmesis rate Participants will be treated with hypofractionated radiotherapy (RT) to whole breast with a dose of 40.05 Gy in 15 fractions (2.67 Gy/die) and a concomitant tumor bed dose of 52.5 Gy (3.5 gy/die)
Official title: Hypofractionated Radiotherapy With Dose Escalated Concomitant Boost for Breast Cancer: a Phase 2 Trial
Key Details
Gender
FEMALE
Age Range
18 Years - 50 Years
Study Type
INTERVENTIONAL
Enrollment
132
Start Date
2020-03-12
Completion Date
2030-03
Last Updated
2025-06-15
Healthy Volunteers
No
Conditions
Interventions
hypofractionated radiotherapy with tumor bed boost
hypofractionated radiotherapy with concomitant/simultaneous tumor bed boost
Locations (1)
Università Campus Biomedico
Roma, Italy