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Neuroimaging of Parkinson's
Sponsor: Washington University School of Medicine
Summary
Parkinson's Disease (PD) is a neurodegenerative disorder caused by dysfunction in both subcortical structures and the cortex. The investigators recently discovered a new brain system called the Somato-Cognitive Action Network (SCAN), which could be a primary locus of dysfunction in PD. Here, the investigators will use magnetic resonance imaging techniques in PD patients to test whether SCAN is critical for PD. The investigators will determine whether SCAN is connected to PD-relevant subcortical structures, and whether PD patients exhibit altered subcortical-to-SCAN connectivity. If successful, this work will identify SCAN as a specific circuit altered in PD patients that can serve as a new target for future neuromodulatory PD therapies.
Official title: Precision Neuroimaging of Parkinson's Disease
Key Details
Gender
All
Age Range
40 Years - Any
Study Type
OBSERVATIONAL
Enrollment
120
Start Date
2025-08-01
Completion Date
2031-01
Last Updated
2026-04-06
Healthy Volunteers
Yes
Conditions
Locations (1)
East Imaging Building
St Louis, Missouri, United States