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Effects of Peripheral Magnetic Stimulation on Cortical Excitability in Healthy Individuals
Sponsor: Universidade Federal de Pernambuco
Summary
This study investigates the immediate effects of different parameters (frequency, intensity, and pulse number) of peripheral magnetic stimulation (rPMS) on cortical excitability in healthy individuals. Using a randomized, double-blind crossover design, the research aims to identify optimal stimulation protocols for modulating neural activity. Outcomes include measurements of motor-evoked potentials (MEPs), intracortical inhibition (ICI), and facilitation (ICF). Findings may enhance non-invasive therapeutic strategies for neurological disorders.
Key Details
Gender
All
Age Range
18 Years - 40 Years
Study Type
INTERVENTIONAL
Enrollment
18
Start Date
2022-10-01
Completion Date
2025-10
Last Updated
2025-06-17
Healthy Volunteers
Yes
Conditions
Interventions
Peripheral magnetic stimulation (90% of RMT + 1 Hz)
Low-frequency stimulation (1 Hz) at 90% of resting motor threshold intensity, delivering a total of 2400 pulses.
Peripheral magnetic stimulation (90% of RMT + 10 Hz)
High-frequency stimulation (10 Hz) at 90% of resting motor threshold intensity, totaling 2400 pulses.
Peripheral magnetic stimulation (90% of RMT + 25 Hz)
High-frequency stimulation (25 Hz) at 90% of resting muscle threshold intensity, with 2400 pulses.
Peripheral magnetic stimulation (100% of RMT + 1 Hz)
Low-frequency (1 Hz), at resting motor threshold intensity (100%) protocol delivering 2400 pulses.
Peripheral magnetic stimulation (100% of RMT + 10 Hz)
High-frequency (10 Hz), at resting motor threshold intensity (100%) protocol delivering 2400 pulses.
Peripheral magnetic stimulation (100% of RMT + 25 Hz)
High-frequency (25 Hz), at resting motor threshold intensity (100%) protocol delivering 2400 pulses.
Peripheral magnetic stimulation (110% of RMT + 1Hz)
Low-frequency (1 Hz), above resting motor threshold intensity (110%) protocol delivering 2400 pulses.
Peripheral magnetic stimulation (110% of RMT + 10Hz)
High-frequency (10 Hz), above resting motor threshold intensity (110%) protocol delivering 2400 pulses.
Peripheral magnetic stimulation (110% of RMT + 25Hz)
High-frequency (25 Hz), above resting motor threshold intensity (110%) protocol delivering 2400 pulses.
Locations (1)
Universidade Federal de Pernambuco
Recife, Pernambuco, Brazil