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Efficacy of Rescue Stenting/Angioplasty After Failed Thrombectomy for Acute Large Intracranial Vascular Occlusion
Sponsor: Beijing Anzhen Hospital
Summary
The primary objective of this study is to evaluate whether rescue stenting therapy can improve neurological functional outcomes after failed endovascular treatment for acute ischemic stroke caused by large vessel occlusion. The study population is divided into two groups: Stent Placement Group: If recanalization is not achieved after 3-5 attempts of thrombectomy, direct stent placement or balloon angioplasty is performed. Continued Thrombectomy Group: If recanalization is not achieved after 3-5 attempts of thrombectomy, at least one additional thrombectomy attempt is performed. The primary efficacy endpoint is the proportion of patients achieving a modified Rankin Scale (mRS) score of 0-2 at 90±7 days. The safety endpoint is the incidence of symptomatic intracranial hemorrhage within 48 hours after randomization.
Official title: Efficacy of Rescue Stenting/Angioplasty After Failed Thrombectomy for Acute Large Intracranial Vascular Occlusion: A Multicenter, Prospective, Open-label, Endpoint-blinded, Randomized Controlled Trial
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
312
Start Date
2025-07-12
Completion Date
2027-04-01
Last Updated
2025-08-13
Healthy Volunteers
No
Conditions
Interventions
Stent placement
For patients who fail thrombectomy, perform stent placement.
Continued Thrombectomy
For patients with failed thrombectomy, perform at least one additional thrombectomy attempt
balloon angioplasty
For patients who fail thrombectomy, perform balloon angioplasty.
Locations (1)
Beijing Anzhen Hospital Affiliated to Capital Medical University
Beijing, Beijing Municipality, China