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Effects of Trans-spinal Magnetic Stimulation on Cortical Excitability in Healthy Individuals
Sponsor: Universidade Federal de Pernambuco
Summary
This study investigates the immediate effects of different parameters (frequency and intensity) of trans-spinal magnetic stimulation (TsMS) on cortical excitability in healthy individuals. Using a randomized, double-blind crossover design, the research aims to identify optimal stimulation protocols for modulating neural activity. Outcomes include measurements of motor-evoked potentials (MEP), intracortical inhibition (ICI), and facilitation (ICF). Findings may enhance non-invasive therapeutic strategies for neurological disorders.
Key Details
Gender
All
Age Range
18 Years - 40 Years
Study Type
INTERVENTIONAL
Enrollment
18
Start Date
2022-10-01
Completion Date
2025-10-30
Last Updated
2025-06-18
Healthy Volunteers
Yes
Conditions
Interventions
Trans-spinal magnetic stimulation (90% MT + 1 Hz)
Low frequency stimulation (1 Hz) at 90% of resting motor threshold intensity, delivering a total of 2400 pulses.
Trans-spinal magnetic stimulation (100% MT + 1 Hz)
Low frequency stimulation (1 Hz) at 100% of resting motor threshold intensity, delivering a total of 2400 pulses.
Trans-spinal magnetic stimulation (110% MT + 1 Hz)
Low frequency stimulation (1 Hz) at 110% of resting motor threshold intensity, delivering a total of 2400 pulses.
Trans-spinal magnetic stimulation (90% + 10 Hz)
High frequency stimulation (10 Hz) at 90% of resting motor threshold intensity, delivering a total of 2400 pulses.
Trans-spinal magnetic stimulation (100% MT + 10 Hz)
High frequency stimulation (10 Hz) at 100% of resting motor threshold intensity, delivering a total of 2400 pulses.
Trans-spinal magnetic stimulation (110% MT + 10 Hz)
High frequency stimulation (10 Hz) at 110% of resting motor threshold intensity, delivering a total of 2400 pulses.
Trans-spinal magnetic stimulation (90% MT + 25 Hz)
High frequency stimulation (25 Hz) at 90% of resting motor threshold intensity, delivering a total of 2400 pulses.
Trans-spinal magnetic stimulation (100% MT + 25 Hz)
High frequency stimulation (25 Hz) at 100% of resting motor threshold intensity, delivering a total of 2400 pulses.
Trans-spinal magnetic stimulation (110% MT + 25 Hz)
High frequency stimulation (25 Hz) at 110% of resting motor threshold intensity, delivering a total of 2400 pulses.
Locations (1)
Universidade Federal de Pernambuco
Recife, Pernambuco, Brazil