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Effect of an Experimental Cannabidiol Gel on Tooth Sensitivity
Sponsor: Universidade Federal do Para
Summary
The goal of this clinical trial will be to evaluate the effect applying an experimental gel based on cannabidiol oil (CBD) on tooth sensitivity induced by tooth bleaching with 35% hydrogen peroxide (HP). Volunteers will be selected and allocated to the following groups: GP - placebo gel, GCBD - experimental cannabidiol gel and GKF - Potassium Nitrate and Sodium Fluoride Gel. In each group, the corresponding desensitizing gel will be applied to on the teeth for 10 minutes. All groups will then undergo in-office whitening treatment with 35% hydrogen peroxide. Patients will be instructed to record tooth sensitivity on a daily basis during the 21 days of follow-up. Pain intensity will be measured using a visual analog scale (VAS), while the risk of developing sensitivity will be recorded after each session of the whitening procedure, with two response option.
Official title: Effect of an Experimental Cannabidiol Gel on Tooth Sensitivity Induced by Tooth Bleaching
Key Details
Gender
All
Age Range
18 Years - 40 Years
Study Type
INTERVENTIONAL
Enrollment
75
Start Date
2025-07-25
Completion Date
2026-07
Last Updated
2025-06-18
Healthy Volunteers
No
Conditions
Interventions
Potassium nitrate and sodium fluoride
Gel with 5% potassium nitrate and 2% sodium fluoride gel of 5% potassium nitrate and 2% sodium fluoride for topical application to teeth before bleaching with hydrogen peroxide
Cannabidiol (CBD) Gel
Cannabidiol gel for teeth ( 2% cannabidiol oil) before bleaching with hydrogen peroxide
Natrosol 4% Gel
placebo gel (natrosol-based gel 4%) for topical application to teeth before bleaching with hydrogen peroxide.
Locations (1)
Federal University of Pará School of Dentistry
Belém, Pará, Brazil