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This Study Will Explore Whether a Combination of the Investigational Drug Mevrometostat (PF-06821497) and Enzalutamide Will Work Better Than Taking Enzalutamide Alone in Participants With mCSPC Who Are ARPI naïve.
Sponsor: Pfizer
Summary
This study will explore whether a combination of the investigational drug mevrometostat (PF-06821497) and enzalutamide will work better than taking enzalutamide alone in participants with mCSPC who are ARPI naïve and have not yet received chemotherapy in the mCSPC setting.
Official title: A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study of Mevrometostat (PF-06821497) With Enzalutamide in Metastatic Castration-Sensitive Prostate Cancer (MEVPRO-3)
Key Details
Gender
MALE
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
1000
Start Date
2025-09-28
Completion Date
2034-12-08
Last Updated
2026-03-30
Healthy Volunteers
No
Conditions
Interventions
Mevrometostat
Oral continuous
Placebo
Oral continuous
Enzalutamide
Oral continuous
Locations (253)
Clearview Cancer Institute (Crestwood)
Huntsville, Alabama, United States
Clearview Cancer Institute
Huntsville, Alabama, United States
Ironwood Cancer & Research Centers
Chandler, Arizona, United States
Ironwood Cancer & Research Centers
Gilbert, Arizona, United States
Ironwood Cancer & Research Centers
Glendale, Arizona, United States
Ironwood Cancer & Research Centers
Goodyear, Arizona, United States
Ironwood Cancer & Research Centers
Mesa, Arizona, United States
Ironwood Cancer & Research Centers
Mesa, Arizona, United States
Ironwood Cancer & Research Centers
Phoenix, Arizona, United States
Ironwood Cancer & Research Centers
Scottsdale, Arizona, United States
Highlands Oncology Group, PA
Fayetteville, Arkansas, United States
Highlands Oncology Group, PA
Rogers, Arkansas, United States
Highlands Oncology Group, PA
Springdale, Arkansas, United States
UCLA Hematology/Oncology - Alhambra
Alhambra, California, United States
UCLA Hematology/Oncology - Atascadero
Atascadero, California, United States
Cedars-Sinai Cancer Beverly Hills (drug treatment and dispensing location)
Beverly Hills, California, United States
Cedars-Sinai Cancer Beverly Hills
Beverly Hills, California, United States
UCLA Hematology/Oncology - Beverly Hills
Beverly Hills, California, United States
UCLA Hematology/Oncology - Burbank
Burbank, California, United States
UCLA Hematology/Oncology - Encino
Encino, California, United States
UCLA Hematology/Oncology - Irvine
Irvine, California, United States
UCLA Hematology/Oncology - Laguna Hills
Laguna Hills, California, United States
Cedars-Sinai Cancer at Cedars-Sinai Medical Center
Los Angeles, California, United States
Ronald Reagan UCLA Medical Center - Drug Information Center
Los Angeles, California, United States
UCLA Department of Medicine - Hematology/Oncology
Los Angeles, California, United States
UCLA Hematology/Oncology
Los Angeles, California, United States
UCLA Hematology/Oncology - Marina del Rey
Marina del Rey, California, United States
UCLA Hematology/Oncology - Pasadena
Pasadena, California, United States
UCLA Hematology/Oncology - Porter Ranch
Porter Ranch, California, United States
UCLA Hematology/Oncology - San Luis Obispo
San Luis Obispo, California, United States
UCLA Hematology/Oncology - Santa Barbara
Santa Barbara, California, United States
UCLA Hematology/Oncology- Santa Monica
Santa Monica, California, United States
UCLA Hematology/Oncology - Torrance
Torrance, California, United States
UCLA Hematology/Oncology - Santa Clarita
Valencia, California, United States
UCLA Hematology/Oncology - Ventura
Ventura, California, United States
UCLA Hematology/Oncology - Westlake
Westlake Village, California, United States
AdventHealth Medical Group Urology of Denver
Denver, Colorado, United States
Cancer Care Specialists of Illinois
Decatur, Illinois, United States
Cancer Care Specialists of Illinois
O'Fallon, Illinois, United States
University of Rochester Medical Center
Rochester, New York, United States
University of Rochester, Cancer Center Pharmacy (Investigational Product)
Rochester, New York, United States
Montefiore Einstein Comprehensive Cancer Center
The Bronx, New York, United States
Montefiore Medical Center- Montefiore Medical Park
The Bronx, New York, United States
Duke Cancer Center Cary
Cary, North Carolina, United States
Duke University Medical Center (location of scans)
Durham, North Carolina, United States
Duke University Medical Center - Duke Cancer Center
Durham, North Carolina, United States
Duke University Medical Center - Duke University Hospital (location of scans)
Durham, North Carolina, United States
Duke University
Durham, North Carolina, United States
Duke Cancer Center Raleigh
Raleigh, North Carolina, United States
Duke Raleigh Hospital
Raleigh, North Carolina, United States
Duke Women's Cancer Care Raleigh (Pharmacy location and location of CT, MRI and Bone scan machines)
Raleigh, North Carolina, United States
University Hospitals Seidman Cancer Center at UH Avon Health Center
Avon, Ohio, United States
TriState Urologic Services PSC Inc. dba The Urology Group
Cincinnati, Ohio, United States
University Hospitals Cleveland Medical Center
Cleveland, Ohio, United States
University Hospitals Seidman Cancer Center at UH Mentor Health Center
Mentor, Ohio, United States
UH Minoff Health Center at Chagrin Highlands
Orange, Ohio, United States
The Centers for Advanced Urology, LLP d/b/a Keystone Urology Specialists
Lancaster, Pennsylvania, United States
Grand Strand Medical Center
Myrtle Beach, South Carolina, United States
Carolina Urologic Research Center, LLC
Myrtle Beach, South Carolina, United States
Parkway Surgery Center
Myrtle Beach, South Carolina, United States
The West Clinic, PLLC dba West Cancer Center
Germantown, Tennessee, United States
Urology Associates, P.C.
Nashville, Tennessee, United States
University of Texas Southwestern Medical Center - Simmons Cancer Center
Dallas, Texas, United States
University of Texas Southwestern Medical Center - William P. Clements, Jr., University Hospital
Dallas, Texas, United States
University of Texas Southwestern Simmons Cancer Center - Redbird
Dallas, Texas, United States
University of Texas Southwestern Medical Center-Zale Lipshy University Hospital
Dallas, Texas, United States
University of Texas Southwestern Medical Center
Dallas, Texas, United States
University of Texas Southwestern Simmons Cancer Center - Fort Worth
Fort Worth, Texas, United States
US Oncology Investigational Product Center (IPC)
Irving, Texas, United States
University of Texas Southwestern Simmons Cancer Center - Richardson/Plano
Richardson, Texas, United States
Huntsman Cancer Institute
Salt Lake City, Utah, United States
Blue Ridge Cancer Care
Blacksburg, Virginia, United States
Blue Ridge Cancer Care
Low Moor, Virginia, United States
Blue Ridge Cancer Care
Roanoke, Virginia, United States
Blue Ridge Cancer Care
Salem, Virginia, United States
Blue Ridge Cancer Care
Wytheville, Virginia, United States
Northwest Medical Specialties, PLLC
Bonney Lake, Washington, United States
Northwest Medical Specialties, PLLC
Federal Way, Washington, United States
Northwest Medical Specialties, PLLC
Gig Harbor, Washington, United States
Northwest Medical Specialties, PLLC
Puyallup, Washington, United States
Northwest Medical Specialties, PLLC
Tacoma, Washington, United States
University of Wisconsin Carbone Cancer Center - Eastpark Medical Center
Madison, Wisconsin, United States
University of Wisconsin Carbone Cancer Center - University Hospital
Madison, Wisconsin, United States
Asociación de Beneficencia Hospital Sirio Libanés
Ciudad Autonoma de Buenos Aires, Buenos Aires, Argentina
Sanatorio Británico
Rosario, Santa Fe Province, Argentina
Instituto de Oncología de Rosario
Rosario, Santa Fe Province, Argentina
Centro Oncologico Korben
Buenos Aires, Argentina
Orange Health Service
Orange, New South Wales, Australia
Sydney Adventist Hospital
Wahroonga, New South Wales, Australia
Icon Cancer Centre Chermside
Chermside, Queensland, Australia
Mater Misericordiae Limited Mater Cancer Care Centre
South Brisbane, Queensland, Australia
ICON Cancer Centre - Kurralta Park
Kurralta Park, South Australia, Australia
Sir Charles Gairdner Hospital
Nedlands, Western Australia, Australia
Institut Jules Bordet
Anderlecht, Bruxelles-capitale, Région de, Belgium
Jessa Ziekenhuis
Hasselt, Limburg, Belgium
AZ Maria Middelares
Ghent, Oost-vlaanderen, Belgium
AZ Sint-Lucas
Ghent, Oost-vlaanderen, Belgium
UZ Leuven
Leuven, Vlaams-brabant, Belgium
AZORG Campus Aalst-Moorselbaan
Aalst, Belgium
CEPHO - Centro de Estudos e Pesquisas de Hematologia e Oncologia
Santo André, São Paulo, Brazil
MBAL Uni Hospital
Panagyurishte, Pazardzhik, Bulgaria
Medical Center Futuremeds
Plovdiv, Bulgaria
Complex Oncology Center - Plovdiv EOOD
Plovdiv, Bulgaria
Prostate Cancer Centre
Calgary, Alberta, Canada
Centre of Applied Urology Research/Nova Scotia Health Authority
Halifax, Nova Scotia, Canada
Centre Intégré de Santé et de Services Sociaux de la Montérégie-Centre
Greenfield Park, Quebec, Canada
Centre Hospitalier de l'Université de Montréal
Montreal, Quebec, Canada
Jewish General Hospital
Montreal, Quebec, Canada
Centre intégré de cancérologie du CHU de Québec Université Laval, Hôpital de l'Enfant-Jésus
Québec, Quebec, Canada
Centre intégré universitaire de santé et de services sociaux de l'Estrie - Centre Hospitalier Univer
Sherbrooke, Quebec, Canada
Diex Recherche Trois-Rivieres
Trois-Rivières, Quebec, Canada
Wannan Medical College Yijishan Hospital
Wuhu, Anhui, China
Peking University First Hospital
Beijing, Beijing Municipality, China
Beijing Friendship Hospital Affiliate of Capital University
Beijing, Beijing Municipality, China
The First Affiliated Hospital of Chongqing Medical University
Chongqing, Chongqing Municipality, China
Chongqing University Cancer Hospital
Chongqing, Chongqing Municipality, China
Lanzhou university second hospital
Lanzhou, Gansu, China
The First Affiliated Hospital of Guangzhou Medical University
Guangzhou, Guangdong, China
Sun Yat-sen University Cancer Center
Guangzhou, Guangdong, China
Union Hospital Tongji Medical College Huazhong University of Science and Technology
Wuhan, Hubei, China
Hunan Cancer Hospital
Changsha, Hunan, China
First Huai'an Hospital Affiliated to Nanjing Medical University
Huai'an, Jiangsu, China
Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School
Nanjing, Jiangsu, China
Nantong Tumor Hospital
Nantong, Jiangsu, China
The Second Affiliated Hospital of Soochow University
Suzhou, Jiangsu, China
The First Hospital of China Medical University
Shenyang, Liangning, China
The First Affiliated Hospital of Xi'an Jiaotong University
Xi'an, Shaanxi, China
Qilu Hospital of Shandong University
Jinan, Shandong, China
Fudan University Shanghai Cancer Center
Shanghai, Shanghai Municipality, China
Suining Central Hospital
Suining, Sichuan, China
Zhejiang Provincial People's Hospital
Hangzhou, Zhejiang, China
Sir Run Run Shaw Hospital of Zhejiang University School of Medicine
Hangzhou, Zhejiang, China
The first affiliated hospital of Ningbo university
Ningbo, Zhejiang, China
The First Affiliated Hospital of Wenzhou Medical University
Wenzhou, Zhejiang, China
The Third Affiliated Hospital of Southern Medical University
Guangzhou, China
Masarykuv onkologicky ustav
Brno, Czechia
Fakultni nemocnice Hradec Kralove
Hradec Králové, Czechia
Fakultni nemocnice Olomouc
Olomouc, Czechia
Urocentrum Praha s.r.o.
Prague, Czechia
Fakultni Thomayerova nemocnice
Prague, Czechia
Fakultni nemocnice v Motole
Prague, Czechia
Oulun yliopistollinen sairaala
Oulu, North Ostrobothnia, Finland
Kuopion Yliopistollinen Sairaala
Kuopio, Northern Savonia, Finland
Tampereen yliopistollinen sairaala
Tampere, Pirkanmaa, Finland
Vaasan Keskussairaala
Vaasa, Pohjanmaa, Finland
Turku University Hospital
Turku, Southwest Finland, Finland
Docrates Syöpäsairaala
Helsinki, Uusimaa, Finland
Centre Antoine-Lacassagne
Nice, Alpes-maritimes, France
Institut Bergonié - Centre Régional de Lutte Contre Le Cancer de Bordeaux et Sud Ouest
Bordeaux, Aquitaine, France
Centre Leon Berard
Lyon Cedex08, Auvergne-Rhône-Alpes, France
Groupe Vivalto Santé - Clinique Pasteur-Lanroze
Brest, Brittany Region, France
CHU Besançon
Besançon, Doubs, France
Institut Godinot
Reims, Marne, France
Institut Jean Godinot
Reims, Marne, France
Centre Hospitalier de la Côte Basque
Bayonne, Pyrénées-atlantiques, France
Centre Hospitalier Lyon Sud
Pierre-Bénite, Rhône, France
Gustave Roussy
Villejuif, Val-de-marne, France
Henri Mondor Hospital
Créteil, Île-de-France Region, France
Studienpraxis Urologie
Nürtingen, Baden-Wurttemberg, Germany
Universitaetsklinikum Ulm
Ulm, Baden-Wurttemberg, Germany
Urologie Neandertal - Praxis Mettmann
Mettmann, North Rhine-Westphalia, Germany
Universitätsklinikum Münster - Albert Schweitzer Campus
Münster, North Rhine-Westphalia, Germany
Charité Universitaetsmedizin Berlin
Berlin, Germany
Metropolitan Hospital
Athens, Greece
Athens Medical Center S.A -European Interbalkan Medical Center
Thessaloniki, Greece
Rabin Medical Center
Petah Tikva, Central District, Israel
Sheba Medical Center
Ramat Gan, Central District, Israel
Yitzhak Shamir Medical Center
Ẕerifin, Central District, Israel
Shaare Zedek Medical Center
Jerusalem, Jerusalem, Israel
Hadassah Medical Center
Jerusalem, Jerusalem, Israel
Rambam Health Care Campus
Haifa, Northern District, Israel
Sourasky Medical Center
Tel Aviv, TELL ABĪB, Israel
IRCCS Istituto Clinico Humanitas
Rozzano, Milano, Italy
Azienda Ospedaliero-Universitaria San Luigi Gonzaga
Orbassano, Piedmont, Italy
Istituto Nazionale Tumori Regina Elena
Rome, ROMA, Italy
Azienda Ospedaliero Universitaria Maggiore della Carità
Novara, Italy
ASUIT Trento - Santa Chiara Hospital
Trento, Italy
Centro Ricerche Cliniche di Verona
Verona, Italy
Chiba cancer center
Chiba, Chiba, Japan
National Hospital Organization Shikoku Cancer Center
Matsuyama, Ehime, Japan
National Hospital Organization Hokkaido Cancer Center
Sapporo, Hokkaido, Japan
Hokkaido University Hospital
Sapporo, Hokkaido, Japan
Kobe University Hospital
Kobe, Hyōgo, Japan
Kanazawa University Hospital
Kanazawa, Ishikawa-ken, Japan
Yokohama City University Medical Center
Yokohama, Kanagawa, Japan
Yokosuka Kyosai Hospital
Yokosuka, Kanagawa, Japan
The University of Osaka Hospital
Suita, Osaka, Japan
Keio university hospital
Shinjuku-ku, Tokyo, Japan
National Hospital Organization Kyushu Cancer Center
Fukuoka, Japan
National Hospital Organization Kumamoto Medical Center
Kumamoto, Japan
Osaka International Cancer Institute
Osaka, Japan
Yamagata University Hospital
Yamagata, Japan
Canisius-Wilhelmina Ziekenhuis
Nijmegen, Gelderland, Netherlands
Tergooi MC
Hilversum, North Holland, Netherlands
Reinier de Graaf Ziekenhuis, locatie Delft
Delft, South Holland, Netherlands
Tauranga Hospital
Tauranga, Bay of Plenty, New Zealand
Christchurch Hospital
Christchurch, Canterbury, New Zealand
Waikato Hospital
Hamilton, Waikato Region, New Zealand
Auckland City Hospital
Auckland, New Zealand
Palmerston North Hospital
Palmerston North, New Zealand
Clinical Research Center Spółka z ograniczoną odpowiedzialnością MEDIC-R Sp.k
Poznan, Greater Poland Voivodeship, Poland
Szpital Specjalistyczny im. Ludwika Rydygiera w Krakowie
Krakow, Lesser Poland Voivodeship, Poland
POLIMED CLINIC Sp. z o.o.
Wroclaw, Lower Silesian Voivodeship, Poland
Zachodniopomorskie Centrum Onkologii
Szczecin, West Pomeranian Voivodeship, Poland
Szpitale Pomorskie Sp. z o.o.
Gdynia, Poland
Szpital Wojewódzki im. Mikołaja Kopernika w Koszalinie
Koszalin, Poland
Szpital Specjalistyczny im. Ludwika Rydygiera w Krakowie Sp. z o .o.
Krakow, Poland
Clinical Best Solutions Sp. z o.o. S.K.
Lublin, Poland
Centrum Medyczne MEDYK
Rzeszów, Poland
Zachodniopomorskie Centrum Onkologii
Szczecin, Poland
EMC Instytut Medyczny S.A.
Wroclaw, Poland
Narodny onkologicky ustav
Bratislava, Slovakia
Vychodoslovensky onkologicky ustav, a.s.
Košice, Slovakia
MILAB, s.r.o., Urologicka ambulancia
Prešov, Slovakia
Privatna urologicka ambulancia, s.r.o.
Trenčín, Slovakia
Chonnam National University Hwasun Hospital
Hwasun-gun, Jeonranamdo, South Korea
National Cancer Center
Goyang-si, Kyǒnggi-do, South Korea
Seoul National University Bundang Hospital
Seongnam, Kyǒnggi-do, South Korea
Seoul National University Hospital
Seoul, Seoul-teukbyeolsi [seoul], South Korea
Severance Hospital, Yonsei University Health System
Seoul, Seoul-teukbyeolsi [seoul], South Korea
Asan Medical Center
Seoul, Seoul-teukbyeolsi [seoul], South Korea
Samsung Medical Center
Seoul, Seoul-teukbyeolsi [seoul], South Korea
Ewha Womans University Mokdong Hospital
Seoul, Seoul-teukbyeolsi [seoul], South Korea
Kyungpook National University Chilgok Hospital
Deagu, Taegu-kwangyǒkshi, South Korea
Chungnam national university hospital
Junggu, Taejǒn-kwangyǒkshi, South Korea
Parc de Salut Mar - Hospital del Mar
Barcelona, Barcelona [barcelona], Spain
Althaia, Xarxa Assistencial Universitària de Manresa
Manresa, Barcelona, Spain
Hospital Clínic de Barcelona
Barcelona, Catalunya [cataluña], Spain
Hospital Universitario Ramón y Cajal
Madrid, Madrid, Comunidad de, Spain
Hospital Universitario Virgen de la Victoria
Málaga, Málaga, Spain
CHUVI- Hospital Alvaro Cunqueiro
Vigo, Pontevedra [pontevedra], Spain
Fundación Instituto Valenciano de Oncología
Valencia, Valenciana, Comunitat, Spain
Hospital Clinico San Carlos
Madrid, Spain
Hospital General Universitario de Valencia
Valencia, Spain
Inselspital Bern
Bern, Canton of Bern, Switzerland
Kantonsspital Winterthur
Winterthur, Switzerland
UniversitätsSpital Zürich
Zurich, Switzerland
Kaohsiung Medical University Chung-Ho Memorial Hospital
Kaohsiung City, Taiwan
Taichung Veterans General Hospital
Taichung, Taiwan
National Cheng Kung University Hospital
Tainan, Taiwan
National Taiwan University Hospital
Taipei, Taiwan
Taipei Veterans General Hospital
Taipei, Taiwan
Chang Gung Medical Foundation-Linkou Branch
Taoyuan District, Taiwan
Royal Blackburn Hospital
Blackburn, Blackburn WITH Darwen, United Kingdom
Velindre Cancer Centre
Cardiff, Cardiff [caerdydd Gb-crd], United Kingdom
Derriford Hospital
Plymouth, Devon, United Kingdom
Torbay Hospital
Torquay, Devon, United Kingdom
Imperial College Healthcare NHS Trust, Charing Cross Hospital
London, Hammersmith and Fulham, United Kingdom
Royal Marsden Hospital (Chelsea)
London, Kensington and Chelsea, United Kingdom
Maidstone Hospital
Maidstone, KENT, United Kingdom
Guy's & St Thomas' NHS Foundation Trust
London, London, CITY of, United Kingdom
Western General Hospital
Edinburgh, Midlothian, United Kingdom
The Christie NHS Foundation Trust
Manchester, United Kingdom