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Prevalence of Human Papillomavirus (HPV) in a Healthy Population: A Feasibility Study of Oropharyngeal Cancer Screening
Sponsor: The Institute of Molecular and Translational Medicine, Czech Republic
Summary
This study defines the prevalence of oral infection with high-risk human papillomaviruses (hrHPV) in individuals over 40 years of age in the Czech Republic. It also establishes an effective methodology for oropharyngeal carcinoma screening and optimization of screening and testing procedures.
Key Details
Gender
All
Age Range
40 Years - Any
Study Type
INTERVENTIONAL
Enrollment
20000
Start Date
2025-06-01
Completion Date
2031-03-30
Last Updated
2026-02-13
Healthy Volunteers
Yes
Conditions
Interventions
Self-sampling by gargling kit at dental clinic
Participants will perform a self-sampling at the dental clinic using gargling kit
Questionnaire
Participants will answer questionnaire online/paper at their home or at the dental clinic
Self-sampling by gargling kit at home
Participants will perform a self-sampling at home using gargling kit
Blood sampling
Venous blood will be collected from study participants with oral hrHPV positivity, in which the presence of circulating hrHPV DNA will be determined.
Self-sampling of the urogenital area
In case of a positive examination in the oropharynx, the tested individuals will be offered a self-collection HPV examination in the urogenital area (cervicovaginal swab in women or external genital swab in men).
Locations (5)
Masaryk Memorial Cancer Institute
Brno, Czechia
Stomatologická klinika, Fakultní nemocnice u sv. Anny
Brno, Czechia
Stomatologické centrum ARTDENT s.r.o.
Jihlava, Czechia
Klinika zubního lékařství Fakultní nemocnice Olomouc
Olomouc, Czechia
CLINIQ Dejvice
Prague, Czechia