Clinical Research Directory
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A Clinical Study of MK-2214 in People With Early Alzheimer's Disease (MK-2214-004)
Sponsor: Merck Sharp & Dohme LLC
Summary
Researchers want to know if the study treatment called MK-2214 works to slow certain changes in the brains of people with Alzheimer's disease (AD). AD is a type of dementia that can cause loss of memory, communication (such as speech), and decision-making skills. It can limit a person's ability to do daily tasks. MK-2214 is a study treatment designed to slow down AD. The goals of the study are to learn: * If MK-2214 slows the spread of tau in the brain compared to placebo. Tau is a protein that accumulates in AD \& damages brain cells. A placebo looks like the study treatment but has no study treatment in it. Using a placebo helps researchers better understand the effects of a study treatment. * About the safety of MK-2214 and if people tolerate it
Official title: A Phase 2 Randomized, Placebo-Controlled, Double-Blind, Parallel-Group Study to Evaluate the Efficacy and Safety of MK-2214 in Participants With Early Alzheimer's Disease
Key Details
Gender
All
Age Range
50 Years - 85 Years
Study Type
INTERVENTIONAL
Enrollment
340
Start Date
2025-07-16
Completion Date
2029-04-30
Last Updated
2026-04-03
Healthy Volunteers
No
Conditions
Interventions
MK-2214
IV infusion
Placebo
IV infusion
Locations (71)
Inglewood Clinical ( Site 1062)
Inglewood, California, United States
Irvine Clinical Research ( Site 1041)
Irvine, California, United States
Healthy Brain Clinic ( Site 1005)
Long Beach, California, United States
Anderson Clinical Research ( Site 1024)
Redlands, California, United States
UCSF Memory and Aging Center ( Site 1031)
San Francisco, California, United States
Syrentis Clinical Research ( Site 1001)
Santa Ana, California, United States
Yale University, Alzheimer's Disease Research Unit ( Site 1059)
New Haven, Connecticut, United States
JEM Research Institute ( Site 1046)
Atlantis, Florida, United States
Neuropsychiatric Research Center of Southwest Florida ( Site 1003)
Fort Myers, Florida, United States
Indago Research & Health Center, Inc ( Site 1044)
Hialeah, Florida, United States
K2 Medical Research ( Site 1047)
Maitland, Florida, United States
ClinCloud LLC ( Site 1039)
Melbourne, Florida, United States
Aqualane Clinical Research ( Site 1035)
Naples, Florida, United States
Suncoast Clinical Research ( Site 1007)
New Port Richey, Florida, United States
Renstar Medical Research ( Site 1012)
Ocala, Florida, United States
Charter Research - Orlando ( Site 1051)
Orlando, Florida, United States
Axiom Brain Health ( Site 1029)
Tampa, Florida, United States
K2 Medical Research ( Site 1020)
Tampa, Florida, United States
Charter Research - Lady Lake ( Site 1019)
The Villages, Florida, United States
Conquest Research LLC ( Site 1053)
Winter Park, Florida, United States
CenExel iResearch, LLC ( Site 1015)
Decatur, Georgia, United States
Alexian Brothers Medical Center-Neurosciences ( Site 1017)
Elk Grove Village, Illinois, United States
Boston Center for Memory ( Site 1008)
Newton, Massachusetts, United States
Clinical Research Professionals ( Site 1004)
Chesterfield, Missouri, United States
The Cognitive and Research Center of New Jersey - Ridgewood ( Site 1064)
Ridgewood, New Jersey, United States
The Cognitive and Research Center of NJ ( Site 1057)
Springfield, New Jersey, United States
CenExel- AMRI ( Site 1018)
Toms River, New Jersey, United States
Alzheimer Disease Research Center (ADRC) ( Site 1000)
Albany, New York, United States
Mid Hudson Medical Research ( Site 1050)
New Windsor, New York, United States
Basil Clinical ( Site 1065)
Queens, New York, United States
Insight Clinical Trials ( Site 1011)
Independence, Ohio, United States
Neuro-Behavioral Clinical Research ( Site 1028)
North Canton, Ohio, United States
Flourish Research ( Site 1048)
Plymouth Meeting, Pennsylvania, United States
Gadolin Research ( Site 1032)
Beaumont, Texas, United States
Horizon Clinical Research Center - Houston ( Site 1026)
Cypress, Texas, United States
Organizacion Medica de Investigacion ( Site 0401)
Ciudad de Buenos Aires, Buenos Aires F.D., Argentina
Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia (FLENI) ( Site 0400)
Caba, Argentina
Southern Neurology ( Site 0306)
Kogarah, New South Wales, Australia
KARA Institute for Neurological Diseases ( Site 0302)
Macquarie Park, New South Wales, Australia
Austin Health ( Site 0300)
Ivanhoe, Victoria, Australia
HammondCare ( Site 0301)
Malvern, Victoria, Australia
Cliniques universitaires Saint-Luc ( Site 3001)
Brussels, Bruxelles-Capitale, Region de, Belgium
UZ Leuven ( Site 3000)
Leuven, Vlaams-Brabant, Belgium
AZ Groeninge Campus Kennedylaan ( Site 3002)
Kortrijk, West-Vlaanderen, Belgium
National Center for Geriatrics and Gerontology ( Site 9002)
Ōbu, Aichi-ken, Japan
Chibaken Saiseikai Narashino Hospital ( Site 9000)
Narashino, Chiba, Japan
Association of Healthcare Corporation Koukankai Koukan Clinic ( Site 9016)
Kawasaki, Kanagawa, Japan
Mie University Hospital ( Site 9011)
Tsu, Mie-ken, Japan
Katayama Medical Clinic ( Site 9005)
Kurashiki, Okayama-ken, Japan
National Hospital Organization Hizen Psychiatric Medical Center ( Site 9004)
Kanzaki-gun, Saga-ken, Japan
Tokyo Medical University Hospital ( Site 9003)
Shinjuku, Tokyo, Japan
Inage Neurology and Memory Clinic ( Site 9001)
Chiba, Japan
Kyushu University Hospital ( Site 9010)
Fukuoka, Japan
Okayama City General Medical Center Okayama City Hospital ( Site 9008)
Okayama, Japan
Brain Research Center Den Bosch B.V. ( Site 5001)
's-Hertogenbosch, North Brabant, Netherlands
Brain Research Center. ( Site 5000)
Amsterdam, North Holland, Netherlands
Brain Research Center Zwolle ( Site 5002)
Zwolle, Overijssel, Netherlands
Hanyang University Hospital ( Site 0200)
Seoul, South Korea
Samsung Medical Center ( Site 0202)
Seoul, South Korea
Ewha Womans University Seoul Hospital ( Site 0201)
Seoul, South Korea
Hospital Universitari Mutua Terrassa ( Site 6004)
Terrassa, Barcelona, Spain
Fundació ACE ( Site 6003)
Barcelona, Catalonia, Spain
Hospital del Mar ( Site 6001)
Barcelona, Spain
Hospital Clinic i Provincial ( Site 6002)
Barcelona, Spain
Scottish Brain Sciences Aberdeen ( Site 8001)
Aberdeen, Aberdeen City, United Kingdom
Scottish Brain Sciences ( Site 8000)
Edinburgh, Edinburgh, City of, United Kingdom
Moorgreen Hospital ( Site 8004)
Southampton, Hampshire, United Kingdom
Leonard Wolfson Experimental Neurology Centre (LWENC) ( Site 8006)
London, London, City of, United Kingdom
Warneford Hospital ( Site 8007)
Oxford, Oxfordshire, United Kingdom
Remind UK ( Site 8003)
Bath, Somerset, United Kingdom
Re:Cognition Health - Birmingham ( Site 8002)
Birmingham, United Kingdom