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Fractional CO₂ Laser or 40% Urea With Topical Fluconazole Microemulsion in Onychomycosis
Sponsor: Assiut University
Summary
To evaluate the efficacy and safety of topical fluconazole microemulsion enhanced by fractional CO₂ laser versus by 40% urea ablation in treatment of Onychomycosis.
Official title: Comparative Study Between Fractional CO₂ Laser and 40% Urea Assisted Delivery of Topical Fluconazole Microemulsion in the Treatment of Onychomycosis
Key Details
Gender
All
Age Range
18 Years - 65 Years
Study Type
INTERVENTIONAL
Enrollment
40
Start Date
2025-06
Completion Date
2026-07
Last Updated
2025-06-29
Healthy Volunteers
Yes
Conditions
Interventions
"Fractional CO2 laser" and "topical fluconazole microemulsion"
four sessions of fractional CO2 at 3weeks interval with a laser device (multixel, Daeshin enterprise co., LTD. (D.S.E) 105, 271, digital -ro, Guro-gu, Seoul, Koreaa) at a pulse energy of 140 mJ, a density of 150 spots/ cm2 and a depth of 1 cm combined with twice daily topical fluconazole microemulsion.
"Urea 40%" and "topical fluconazole microemulsion"
urea 40% paste under occlusion once daily over 4 weeks followed by topical fluconazole microemulsion twice daily for 8 weeks.