Clinical Research Directory

Inclusion Criteria: * Male or female ≥ 18 years of age at Visit 1. * Documentation of NFPA as evidenced by diagnostic criteria and size ≥ 0.5 cm in diameter. * Absence of previous hormonal pituitary hypersecretion, except prolactin level ≤ 30 ng/ml * Absence of previous radiotherapy or radiosurgery * Written informed consent Exclusion Criteria: * Allergic to cabergoline or ergotamine * Currently receiving cabergoline * With moderate to severe symptoms of mass effect, such as visual defect, headache, cranial nerve palsy. * AST, ALT over 2.5 times of the upper limit. * Chronic kidney disease, stage 4 and 5. * Hypotension * History of congestive heart failure, NYHA Fc III, IV * History of moderate or severe valvular heart disease. * History of Parkinson's disease. * History of pulmonary fibrosis * Pregnant, breastfeeding, or unwilling to practice birth control during participation in the study. * History of previous pituitary surgery or radiotherapy * Psychotic psychiatric disease * Active gastrointestinal tract bleeding * History of Raynaud's phenomenon * Presence of a condition or abnormality that in the opinion of the Investigator would compromise the safety of the patient or the quality of the data.