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Effect of Sevoflurane on Sweat Threshold in Children of Different Ages
Sponsor: Second Affiliated Hospital of Wenzhou Medical University
Summary
Hypothermia is a common complication in pediatric anesthesia. Hypothermia will prolong the recovery time of anesthesia, and may also lead to increased oxygen consumption, prolonged blood coagulation time, and affect the metabolism of anesthetic drugs and postoperative immune function. Sevoflurane is the most commonly used inhaled anesthetic in children. This study explored the effect of sevoflurane on the sweat threshold of pediatric patients and analyzed the characteristics of body temperature regulation in children of different ages under anesthesia, which will help to understand the mechanism of body temperature regulation in children under anesthesia, and also provide a scientific basis for clinical anesthesia temperature management.
Key Details
Gender
All
Age Range
Any - 12 Years
Study Type
INTERVENTIONAL
Enrollment
100
Start Date
2025-06
Completion Date
2026-06
Last Updated
2025-06-25
Healthy Volunteers
Yes
Interventions
temperature monitoring
Core temperature will be measured in the distal esophagus. The esophageal probe will be inserted after intubation to the depth from the upper incisors recommended by Bloch et al,1 specifically one-quarter of the patient's height plus 4.5 cm.
Sevoflurane
Anesthesia induction will be standardized for all participants., the children will undergo inhalational induction using 8% sevoflurane with a fresh gas flow of 5 L/min in 100% oxygen. Once children loses consciousness, the sevoflurane concentration will be reduced to 3%-5% and then maintained as close as possible to 1.2 MAC, age-adjusted
Locations (1)
The second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University Wenzhou
Wenzhou, Zhejiang, China