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Understanding Cycles to Improve Women's Health
Sponsor: University Hospital, Montpellier
Summary
Introduction: The C-HEALTH study investigates how environmental and socio-economic conditions affect women's menstrual cycles and reproductive health. Aim: To compare progesterone levels during the luteal phase among women from different socio-economic backgrounds living in rural and urban areas in southern France. Methods: This is a prospective observational study involving 320 healthy women of reproductive age. * Hormones (progesterone, estradiol) will be measured daily in saliva. * Inflammation (Protéine C Réactive: CRP) will be measured five times per cycle via blood drops. * Participants will wear a smart ring to monitor body temperature and activity. * Daily symptoms and lifestyle data will be collected. * Environmental exposures (pollution, stress, living conditions) will be assessed and linked to menstrual health outcomes.
Official title: Understanding Socio-ecological Variation in Menstrual Cycles to Advance Female Health
Key Details
Gender
FEMALE
Age Range
18 Years - 39 Years
Study Type
OBSERVATIONAL
Enrollment
320
Start Date
2025-09-01
Completion Date
2029-07-01
Last Updated
2025-11-28
Healthy Volunteers
Yes
Interventions
Self-saliva sampling
Self-saliva samples are taken every day from D1 inclusive over 1 consecutive cycle, to measure progesterone (P4) and estradiol (E2) concentrations.
Self-collection of dried blood spots
Self-blood sampling is done 5 times during the cycle to measure protéine C-Réactive (CRP) concentrations.
Wearing the connected ring
A connected ring is worn every day of the observed cycle, while maintaining lifestyle habits, to measure daily body temperature, assess heart rate variability and resting heart rate, evaluate physical activity and energy expenditure, assess stress level, and evaluate sleep quality.
Ovulation test
An ovulation test (Ovulatest®) is carried out from day 7 until a test is positive, or until day 39 if ovulation is not detected
Locations (1)
Institute of Evolutionary Science of Montpellier
Montpellier, France