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Women With isoLated acUte cyStitis and Macroscopic Hematuria. Is Further Investigation Needed?
Sponsor: Vastra Gotaland Region
Summary
This prospective multicenter observational study evaluates whether women ≥50 years with isolated acute hemorrhagic cystitis (AHC) and macroscopic hematuria require full malignancy workup. All participants undergo standard diagnostics (cystoscopy, CT urography, cytology), with 12-month follow-up for cancer detection. The aim is to identify low-risk patients where invasive investigations may be safely avoided.
Official title: Women With isoLated acUte cyStitis and Macroscopic Hematuria. Is Further Investigation Needed? A Prospective Multicenter Study. BLUSH Trial
Key Details
Gender
FEMALE
Age Range
18 Years - 110 Years
Study Type
OBSERVATIONAL
Enrollment
300
Start Date
2025-10-13
Completion Date
2027-08-30
Last Updated
2025-11-21
Healthy Volunteers
Yes
Interventions
investigation setting (cystoscopy + CTU + cytology)
Observational study. All patients in this group undergo standard diagnostic evaluation including cystoscopy, CT urography, and urine cytology (if clinically indicated), performed during initial assessment for acute macroscopic hematuria.
Cystoscopy - CTU - cytology (if needed)
All patients in this group undergo standard diagnostic evaluation including cystoscopy, CT urography, and urine cytology (if clinically indicated), performed during initial assessment for atypical or chronic presentations of macroscopic hematuria.
Locations (1)
Uddevalla Hospital
Uddevalla, Sweden