Clinical Research Directory

The Impact of Different Sedation Regimens on Hemodynamics in Patients Undergoing Mechanical Ventilation With Shock

Sponsor: Peking University People's Hospital

Summary

Mechanical ventilation is a common therapeutic intervention in the intensive care unit (ICU). However, patients undergoing mechanical ventilation often experience agitation, unplanned extubation, patient-ventilator asynchrony, and even neuroendocrine-immune dysregulation, sympathetic overexcitation, and organ dysfunction due to discomfort and pain. Sedation therapy mitigates patient stress, enhances comfort, and ensures the smooth implementation of mechanical ventilation, making it an essential component of treatment for ventilated patients. Nevertheless, sedation may impact peripheral vascular tone, leading to hemodynamic instability and exacerbating inadequate peripheral perfusion. The precise implementation of sedation therapy to minimize adverse effects remains unclear. This prospective observational study will enroll critically ill patients with shock requiring mechanical ventilation. We will examine the effects of different sedation strategies-including sedation assessment protocols, sedative types, sedation duration, and daily awakening trials-on hemodynamics in this population. The study aims to explore optimized sedation regimens and provide evidence-based guidance for precision sedation therapy in clinical practice.

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