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COMPLETED
NCT07037940
NA

Physician Response Evaluation With Contextual Insights vs. Standard Engines - Artificial Intelligence RAG vs LLM Clinical Decision Support

Sponsor: Montefiore Medical Center

View on ClinicalTrials.gov

Summary

Clinical decision support tools powered by artificial intelligence (AI) are being rapidly integrated into medical practice. Two leading systems currently available to clinicians are OpenEvidence, which uses retrieval-augmented generation to access medical literature, and GPT-4, a large language model. While both tools show promise, their relative effectiveness in supporting clinical decision-making has not been directly compared. This study aims to evaluate how these tools influence diagnostic reasoning and management decisions among internal medicine physicians.

Official title: Comparing OpenEvidence and GPT-4 for Diagnostic Reasoning and Management Decisions: A Randomized Trial

Key Details

Gender

All

Age Range

25 Years - Any

Study Type

INTERVENTIONAL

Enrollment

41

Start Date

2025-07-03

Completion Date

2025-12-30

Last Updated

2026-08-11

Healthy Volunteers

Yes

Interventions

OTHER

OpenEvidence

Medical information platform which uses retrieval-augmented generation to access medical literature

OTHER

GPT-4

A chatbot application developed that uses GPT-4, a large language model, to engage in conversational interactions with users.

Locations (2)

Harvard Beth Israel Deaconess Medical Center

Boston, Massachusetts, United States

MontefioreMC

The Bronx, New York, United States