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Investigation of Lymph Node Biology in Kidney Cancer
Sponsor: Yale University
Summary
The purpose of this pilot study is to investigate the phenotype, anti-tumor effector functions, and TCR repertoire of T cells isolated from patient tumor draining lymph nodes (TDLNs) to understand T cell priming and trafficking patterns in Renal Cell Carcinoma (RCC). Data and biospecimen collected will be used for current and future research projects involving the study of kidney cancer biology and related medical conditions. We will use this valuable resource to ask clinically relevant translational questions that pertain to biomarker discovery/validation, identification of novel therapeutic targets, and to better understand the genetic and biological basis of the various kidney cancers.
Official title: Characterizing the Tumor-draining Lymph Nodes and Other Immune Sites in Renal Cell Carcinoma
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
10
Start Date
2026-01-30
Completion Date
2027-12
Last Updated
2026-02-03
Healthy Volunteers
Yes
Conditions
Interventions
Peripheral Blood Sample for Immune Analysis
A peripheral blood sample will be collected at the time of surgery.
Tumor Sample for Analysis
Extra tumor which is left over following clinical diagnoses will be collected.
Adjacent non-malignant kidney for analysis
Extra normal tissue which is left over following clinical diagnoses will be collected.
Draining lymph node(s) for analysis
Draining lymph nodes which have been identified by the surgeon visually, potentially using a tracer (injection of up to 5mg of ICG into the peritumor kidney) will be collected.
Regional non-draining lymph node(s) for analysis
Regional lymph nodes which have been deemed as non-draining by the surgeon will be collected.
Locations (1)
Yale University
New Haven, Connecticut, United States