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NOT YET RECRUITING
NCT07038863
NA

Community Screening and Management of Hepatitis B, C and Delta in the Mongolian Population Living in France

Sponsor: Hospices Civils de Lyon

View on ClinicalTrials.gov

Summary

In Mongolia, mortality from hepatocellular carcinoma (HCC) is one of the highest in the world. Viral hepatitis is the main cause of HCC: the prevalence of hepatitis B (HBV) estimated at 11% In Mongolia, hepatitis C (HCV) at 8.5%, and hepatitis Delta (HDV) at 40-60% in HBV-infected patients. Viral hepatitis are essentially asymptomatic and therefore require systematic screening for diagnosis. Once a diagnosis of chronic viral infection has been established, specific therapies are available to reduce the morbidity and mortality of these patients. A study carried out in California in the Mongolian community found an HBV prevalence of 9.7% and positive HDV serology in 41% of these patients. There is a large Mongolian community in France, estimated at between 5,000 and 6,000 patients. Although the majority of these patients are covered by French social security; however, access to care and screening for viral hepatitis often remain difficult and insufficient for migrant or vulnerable populations in France The aim of this study is to screen the Mongolian community in France for viral hepatitis, and then initiate a program of care and treatment.

Official title: Community Screening for Hepatitis B, C and Delta in the Mongolian Population Living in France

Key Details

Gender

All

Age Range

15 Years - Any

Study Type

INTERVENTIONAL

Enrollment

2000

Start Date

2025-09-01

Completion Date

2028-05-01

Last Updated

2025-06-26

Healthy Volunteers

No

Interventions

DIAGNOSTIC_TEST

Community screening for hepatitis B, C and delta in the Mongolian population living in France

Screening will be organised in 11 centres in France, with 1 to 3 screening sessions per centre: patients will be informed of these screening sessions by the Mongolian Embassy in France, social networks and communities. During this screening visit, Rapid Diagnostic Orientation Test (RDOT) will be carried out to screen for HBV and HCV. If the RDOT is negative for both viruses, an information on transmission and prevention of viral infection will be given. If the RDOT is positive, confirmation of these tests by blood sampling will be organized and complementary biology (ASAT, ALAT, GGT, PAL, bilirubin total, bilirubin conjugated). If HBV RDOT positive, additional tubes will be collected for centralized analysis at the end of the study (VHD DNA, VHD genotyping, fibrotest and LCR1/2 test). Once these confirmatory tests have been carried out, the patient will be referred to a hepatology consultation.

Locations (11)

Centre Hospitalier Annecy Genevois

Annecy, France

Centre Expert Hépatites Virales Aquitaine, CHU de Bordeaux

Bordeaux, France

CHU de Clermont Ferrand

Clermont-Ferrand, France

Hôpital Henri Mondor - Assistante Publique Hopitaux de Paris (APHP)

Créteil, France

CHU Grenoble Alpes

Grenoble, France

CHRU Lille

Lille, France

Service d'Hépatologie, Institut d'hépatologie de Lyon, Hôpital Croix-Rousse, Hospices Civils de Lyon

Lyon, France

CHRU Rennes Pontchaillou

Rennes, France

CHU de Rouen

Rouen, France

Hôpitaux Universitaires de Strasbourg

Strasbourg, France

CHRU Bretonneau

Tours, France