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Evaluation of Ketamine/Midazolam Sedation vs. Fentanyl/Midazolam Sedation for Image-Guided Percutaneous Procedures in Interventional Radiology
Sponsor: CAMC Health System
Summary
This study aims to reduce pain during interventional radiology (IR) procedures, making the experience better for patients. Typically, doctors use medications like fentanyl and midazolam for sedation. This research will focus on patients undergoing biopsies and drainage procedures, often associated with significant discomfort. Patients will be randomly assigned to receive either fentanyl/midazolam or ketamine/midazolam combinations for sedation. A coordinator will collect information on pain levels and satisfaction, as well as monitor any extra medications needed and side effects. The investigators hope to find that ketamine helps decrease pain and improves satisfaction compared to fentanyl, without increasing complications.
Official title: Prospective Single-Blinded Randomized Study of Ketamine/Midazolam Sedation vs. Fentanyl/Midazolam Sedation for Image-Guided Percutaneous Procedures in Interventional Radiology
Key Details
Gender
All
Age Range
18 Years - 90 Years
Study Type
INTERVENTIONAL
Enrollment
276
Start Date
2025-03-07
Completion Date
2026-06
Last Updated
2026-02-23
Healthy Volunteers
No
Interventions
ketamine
This is the experimental intervention to be used as an alternative sedation method to the other comparator intervention (fentanyl).
fentanyl
This is the traditional (comparator) intervention used in interventional radiology procedure sedation.
Midazolam
Adjuvant administered in combination with either fentanyl (comparator) or ketamine (experimental).
Locations (1)
CAMC Memorial
Charleston, West Virginia, United States