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Hemodynamic Effects of Intradermal Methylene Blue During Breast Surgery Under General Anesthesia
Sponsor: Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital
Summary
This prospective observational study aims to evaluate the effects of intradermal methylene blue injection on intraoperative hemodynamic stability in patients undergoing breast surgery under general anesthesia. While methylene blue is commonly used for sentinel lymph node mapping, its potential systemic vasopressor effects remain unclear. To provide a comprehensive analysis, the study will compare patients receiving methylene blue with a control group of patients undergoing similar breast procedures without the use of any dye. Hemodynamic parameters such as blood pressure, heart rate, and oxygen saturation will be recorded and compared between the two groups to determine the specific impact of methylene blue on the incidence of intraoperative hypotension and the need for vasopressor support.
Official title: The Effect of Intradermal Methylene Blue Application on Hemodynamic Stability Under General Anesthesia in Breast Surgery: A Prospective Observational Study
Key Details
Gender
FEMALE
Age Range
18 Years - 70 Years
Study Type
OBSERVATIONAL
Enrollment
220
Start Date
2025-07-01
Completion Date
2026-01-10
Last Updated
2026-04-30
Healthy Volunteers
Yes
Conditions
Interventions
Methylene Blue
Intradermal injection of 5 mL of 1% methylene blue solution administered into the breast tissue for sentinel lymph node mapping during breast cancer surgery. The dye is used to identify the first lymph nodes draining from the tumor site.
Standard Surgical Care Without Dye
Patients undergo standard breast surgery (mastectomy or lumpectomy) without administration of methylene blue or any other lymphatic mapping agent. All other perioperative care follows institutional standard protocols.
Locations (1)
Dr. Abdurrahman Yurtaslan Ankara Oncology Education and Research Hospital Clinic of Anesthesiology and Rea
Ankara, Yenimahalle, Turkey (Türkiye)