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Comparison of Omeprazole vs Vonoprazon in Treatment of H Pylori Infection
Sponsor: Rehman Medical Institute - RMI
Summary
Current studies have primarily focused on comparing the advantages and disadvantages of P-CAB and PPI drugs, with little comparison between different P-CAB drugs or between regimens with varying drug combinations and treatment durations. This study aims to evaluate the clinical effectiveness of vonoprazan-based H. pylori eradication therapy and compare it to that of conventional PPI based therapy in clinical practice.
Official title: Comparative Efficacy of Omeprazole and Vonoprazan in the Treatment of Helicobacter Pylori Infection
Key Details
Gender
All
Age Range
12 Years - Any
Study Type
INTERVENTIONAL
Enrollment
128
Start Date
2025-07
Completion Date
2026-02
Last Updated
2025-06-27
Healthy Volunteers
Yes
Conditions
Interventions
Clarithromycin 500 mg
Clarithromycin 500 mg orally twice daily for 14 days
Amoxicillin 1 g
Omeprazole 40 mg orally twice daily for 14 days, then 40 mg once daily for 4 weeks
Omeprazole 40 mg
Omeprazole 40 mg orally twice daily for 14 days, then 40 mg once daily for 4 weeks
Clarithromycin 500 mg
Clarithromycin 500 mg orally twice daily for 14 days
Amoxicillin 1 g
Amoxicillin 1 g orally twice daily for 14 days
Vonoprazan 20 mg
Vonoprazan 20 mg orally twice daily for 14 days, then 20 mg once daily for 4 weeks
Levofloxacin 500 mg
Levofloxacin 500 mg orally once daily for 14 days
Amoxicillin 1 g
Amoxicillin 1 g orally twice daily for 14 days
Omeprazole 40 mg
Omeprazole 40 mg orally twice daily for 14 days, then 40 mg once daily for 4 weeks
Levofloxacin 500 mg
Levofloxacin 500 mg orally once daily for 14 days
Amoxicillin 1 g
Amoxicillin 1 g orally twice daily for 14 days
Vonoprazan 20 mg
Vonoprazan 20 mg orally twice daily for 14 days, then 20 mg once daily for 4 weeks
Locations (1)
Rehman Medical Institue
Peshawar, K, Pakistan