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Low-Flow Anesthesia and Perioperative Atelectasis in Laparoscopic Bariatric Surgery
Sponsor: Istanbul University
Summary
The goal of this clinical trial is to learn whether low-flow anesthesia reduces perioperative atelectasis compared to normal-flow anesthesia in adults undergoing laparoscopic bariatric surgery. The main questions it aims to answer are: Does low-flow anesthesia result in a smaller increase in lung ultrasound score from baseline to postoperative hour 1? Does low-flow anesthesia result in better preservation of pulmonary function at postoperative hour 48? Researchers will compare low-flow anesthesia (fresh gas flow 0.5 L/min) to normal-flow anesthesia (fresh gas flow 2 L/min) to see if low-flow anesthesia reduces the extent of perioperative atelectasis as measured by lung ultrasound. Participants will: Be randomly assigned to receive either low-flow or normal-flow inhalational anesthesia with sevoflurane during surgery Undergo lung ultrasound assessments before surgery and at postoperative hours 1 and 24 Undergo spirometric testing one day before surgery and at postoperative hour 48
Official title: Effect of Low-Flow Anesthesia on Perioperative Atelectasis in Patients Undergoing Laparoscopic Bariatric Surgery: A Randomized Controlled Trial
Key Details
Gender
All
Age Range
18 Years - 65 Years
Study Type
INTERVENTIONAL
Enrollment
60
Start Date
2026-01-15
Completion Date
2026-04-15
Last Updated
2026-05-20
Healthy Volunteers
No
Interventions
Sevoflurane with normal-flow anesthesia
Sevoflurane is delivered via inhalation with a fresh gas flow of 2 L/min throughout surgery. Vaporizer is set to 2.5%.
Sevoflurane with low-flow anesthesia
Sevoflurane is delivered via inhalation. Anesthesia is initiated at FGF 4 L/min with vaporizer at 6% for rapid equilibration. Once end-tidal sevoflurane reaches 1.0 MAC, FGF is reduced to 0.5 L/min and titrated to maintain 1.0 MAC.
Locations (1)
Göztepe Prof.Dr. Süleyman Yalçın Şehir Hastanesi
Istanbul, Goztepe, Turkey (Türkiye)