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Bioavailability of Different Vitamin K Vitamers Studied Using 13C-labelled Vitamin K Vitamers
Sponsor: University of Copenhagen
Summary
Objectives The main objectives are: Study part I: to investigate the bioavailability of vitamin K vitamers (PK, MK-4, MK-7 and MK-9) in humans using 13C-labelled compounds Hypotheses Study part I: it is hypothesized that there is a difference between the bioavailability of the different vitamers, with MK-9 having the highest bioavailability followed by MK-7, and then PK, while MK-4 will have the lowest bioavailability. Participants will: Study part I: In the pilot study and study part I, participants will visit NEXS for a test period where a 6.5-hour test day will be carried out and followed up with two short visits on the 2 consecutive days. In the pilot study, there will be one test period with frequent blood sampling (before and after ingestion of a labelled vitamin K vitamer) and urine and faeces sampling. The minimum duration for each participant in the pilot study will be 2.5 weeks. After analyses of the bioavailability of the vitamin K vitamers in the pilot study, results will be used to determine the time points for biological sampling (mainly blood) in study part I. Study part I is a cross-over study with 4 test periods and washout periods in between. The minimum duration for each participant will be 6 weeks.
Official title: Bioavailability of Micronutrients With a Special Focus on Vitamin K - Study Part I: K-vitamin
Key Details
Gender
All
Age Range
18 Years - 65 Years
Study Type
INTERVENTIONAL
Enrollment
20
Start Date
2025-07-01
Completion Date
2031-06-30
Last Updated
2025-06-27
Healthy Volunteers
Yes
Conditions
Interventions
Vitamin K
each participant will recive one dose of each of the four vitamin K vitamers but in different orders (4 different orders).
Locations (1)
University of Copenhagen
Frederiksberg C, Denmark