Clinical Research Directory

Inclusion Criteria: * Supratentorial non-lacunar ischemic stroke, including anterior, middle, and posterior cerebral artery territories * Aged 18 to 80 years * Symptom onset or symptom recognition to admission \< 12 hours * NIHSS score ≥ 4 and ≤ 20 at enrollment * Signed informed consent form obtained from the participant or their legal representative Exclusion Criteria: * Prior stroke * Previous diagnosis of OSA with current CPAP use or previously failed CPAP * Pre-stroke disability (mRS \> 1) * Coma or stupor * Orotracheal intubation * Clinical instability or severe pre-existing illness (e.g., heart failure, oxygen-dependent COPD, renal or hepatic failure) * Psychomotor agitation * High likelihood of neurosurgical intervention within the first 48 hours * Oxygen therapy \>2 L/min * Known severe neurological disease (e.g., dementia, Parkinson's disease, multiple sclerosis, or other neurodegenerative conditions) * Chronic alcohol or drug use with high risk of withdrawal during hospitalization * Pregnant or suspected pregnant women * Inability to complete follow-up for any reason * Any contraindication to CPAP use