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Improving Personalized Treatment in Oncology: Effects of Integrated Oncological Decision-making
Sponsor: Leiden University Medical Center
Summary
The research aims to evaluate an Integrated Oncological Decision-making Model (IODM) to tailor oncological treatment plans to individual patients. The primary objective is to assess the impact of the IODM on personalized decision-making and patient outcomes. The study will employ a stepped-wedge cluster randomized trial design involving eight oncological care paths across four medical centers in the Netherlands. The study population consists of 400 adult patients (50 per care path) who will undergo treatment based on either standard clinical guidelines (control) or the IODM (intervention). The intervention involves integrating three key components: oncological treatment options, patient's general health status, and patient's goals and preferences. The main study parameters include measuring the discordance between recommendations based on medical information and final treatment decisions, assessing whether discordance reflects more personalized decision-making, and evaluating the implementation process of the IODM.
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
400
Start Date
2024-03-25
Completion Date
2026-03
Last Updated
2025-07-02
Healthy Volunteers
No
Conditions
Interventions
Integrated Oncological Decision-making Model
In the IODM-based practice, the following three information components should be incorporated when forming a personalized treatment plan: 1. State-of-the-art oncological treatment options with advantages and disadvantages; 2. General health status based on physical, psychosocial, and emotional functioning; 3. Goals and preferences of the patient, both in treatment and daily life. Together with the professionals, optimal tools and strategies to integrate these components within the care path will be discussed.
Locations (4)
University Medical Center Groningen (UMCG)
Groningen, Netherlands
Leiden University Medical Center (LUMC)
Leiden, Netherlands
Maastricht University Medical Center
Maastricht, Netherlands
Zuyderland MC
Sittard, Netherlands