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RECRUITING
NCT07047105
NA

Investigation of the Acute Effects of Nepalese Pepper Extract (Zanthoxylum Armatum DC) on Cognitive Function, Mood and Gaming Performance in Young, Healthy, Competitive Gamers

Sponsor: Northumbria University

View on ClinicalTrials.gov

Summary

The goal of this clinical trial is to learn if a Nepalese Pepper Extract (Zanthoxlum Armatum, ZA) supplement can improve cognitive performance and mental abilities in competitive gamers aged 16 to 34. The main questions it aims to answer are: 1. Does ZA supplement improve cognitive abilities like attention, memory, and decision-making? 2. What is the most effective dose of ZA supplement (300mg vs 150mg)? 3. How do the effects of ZA supplement compare to caffeine? Researchers will compare four different treatments (high-dose ZA, low-dose ZA, caffeine, and placebo) to see if ZA supplement produces better cognitive performance than placebo and how it compares to caffeine\*\*. Participants will: * Complete a screening visit with health checks and training on computer tasks * Attend four testing visits (7-14 days apart) where they receive different treatments * Avoid alcohol and energy drinks for 24 hours before each visit, and caffeine from waking * Take assigned treatment at 11:30am and complete cognitive tests at -1, 1, 3, and 5 hours in relation to dose. * Complete mood questionnaires, sleep assessments, and gaming-specific tasks (aim training, character control) * Wear heart rate monitors during testing * Eat standardized meals provided during visits * Play competitive games at home in the evening and complete performance questionnaires

Key Details

Gender

All

Age Range

16 Years - 34 Years

Study Type

INTERVENTIONAL

Enrollment

60

Start Date

2025-06-13

Completion Date

2026-05

Last Updated

2025-07-02

Healthy Volunteers

Yes

Interventions

DIETARY_SUPPLEMENT

Nepalese Pepper (Zanthoxylum Armatum) extract 150mg

The intervention is a powdered form of Zanthoxylum Armatum (ZA) extract delivered in capsule form. The dosage is 150mg.

DIETARY_SUPPLEMENT

Nepalese Pepper (Zanthoxylum Armatum) extract 300mg

The intervention is a powdered form of Zanthoxylum Armatum (ZA) extract delivered in capsule form. The dosage is 300mg.

DIETARY_SUPPLEMENT

Placebo

Microcristalline Cellulose MCC

DIETARY_SUPPLEMENT

Caffeine 75mg

Caffeine anhydrous Pulver, 75mg

Locations (1)

Northumbria University - Brain Performance and Nutrition Research Centre

Newcastle upon Tyne, United Kingdom