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TQB2930 Injection for the Treatment of HER2-positive Advanced Breast Cancer
Sponsor: Chia Tai Tianqing Pharmaceutical Group Nanjing Shunxin Pharmaceutical Co., Ltd.
Summary
TQB2930 is a HER2 bispecific antibody drug. This study aims to evaluate the efficacy and safety of TQB2930 combined with investigator's choice of chemotherapy versus trastuzumab combined with investigator's choice of chemotherapy in subjects with HER2-positive advanced breast cancer who have received at least two prior lines of anti-HER2 therapy in the advanced station.
Official title: A Randomized, Open-label, Parallel-controlled, Multicenter Phase III Clinical Study Evaluating TQB2930 Combined With Investigator's Choice of Chemotherapy Versus Trastuzumab Combined With Investigator's Choice of Chemotherapy in the Treatment of HER2-Positive Advanced Breast Cancer
Key Details
Gender
All
Age Range
18 Years - 75 Years
Study Type
INTERVENTIONAL
Enrollment
416
Start Date
2025-07-25
Completion Date
2028-12
Last Updated
2026-02-02
Healthy Volunteers
No
Conditions
Interventions
TQB2930+ chemotherapy
TQB2930 injection is a HER2 bispecific antibody drug； Chemotherapy: Capecitabine Tablets, Gemcitabine Hydrochloride for Injection, Vinorelbine Tartrate Injection and Eribulin Mesylate Injection are Chemotherapy Drugs.
Trastuzumab+ chemotherapy
Trastuzumab is a HER2-specific targeted drug； Capecitabine Tablets, Gemcitabine Hydrochloride for Injection, Vinorelbine Tartrate Injection and Eribulin Mesylate Injection are Chemotherapy Drugs.
Locations (69)
The First Affiliated Hospital of Bengbu Medical College
Bengbu, Anhui, China
Anhui Provincial Hospital( The First Affiliated Hospital of USTC)
Hefei, Anhui, China
The Second Affiliated Hospital of Anhui Medical University
Hefei, Anhui, China
Chong Qing University Cancer Hospital
Chongqing, Chongqing Municipality, China
Fuzhou First Generel Hospital Affiliated with Fujian Medical University
Fuzhou, Fujian, China
Gansu Cancer Hospital
Lanzhou, Gansu, China
Sun Yat - sen University Cancer Center
Guangzhou, Guangdong, China
Peking University Shenzhen Hospital
Shenzhen, Guangdong, China
Liuzhou People's Hospital
Liuchow, Guangxi, China
Affiliated Cancer Hospital of Guangxi Medical Universit
Nanning, Guangxi, China
The Affiiated Cancer Hospital of Guizhou Medical University
Guiyang, Guizhou, China
Guizhou Provincial People's Hospital
Guiyang, Guizhou, China
Hainan General Hospital
Haikou, Hainan, China
The First Hospital of Qinhuangdao
Qinhuangdao, Hebei, China
The Fourth Hospital of Hebei Medical University
Shijiazhuang, Hebei, China
Tangshan People's Hospital
Tangshan, Hebei, China
Harbin Medical University Cancer Hospital
Harbin, Heilongjiang, China
The First Affiliated Hospital of Harbin Medical University
Harbin, Heilongjiang, China
Jiamusi Tuberculosis Hospital (Jiamusi Tumor Hospital)
Jiamusi, Heilongjiang, China
Mudanjiang Cancer Hospital
Mudanjiang, Heilongjiang, China
AnYang Tumor Hospital
Anyang, Henan, China
The First Affiliated Hospital of Henan University of Science & Technology
Luoyang, Henan, China
Nanyang Second General Hospital
Nanyang, Henan, China
The First Affiliated Hospital of Xinxiang Medical University
Xinxiang, Henan, China
Henan Cancer Hospital
Zhengzhou, Henan, China
Jingmen People's Hospital
Jingmen, Hubei, China
Xiangyang Central Hospital
Xiangyang, Hubei, China
The First People's Hospital of Changde City
Changde, Hunan, China
Hunan Cancer Hospital
Changsha, Hunan, China
People's Hospital of Hunan Province
Changsha, Hunan, China
Xiangya Hospital of Central South University
Changsha, Hunan, China
The Central Hospital of Yongzhou
Yongzhou, Hunan, China
Zhangjiajie People's Hospital
Zhangjiajie, Hunan, China
JiangSu Cancer Hosipital
Nanjing, Jiangsu, China
The Affiliated Sir Run Run Hospital of Nanjing Medical University
Nanjing, Jiangsu, China
Nanjing Drum Tower Hospital
Nanjing, Jiangsu, China
Zhangjiagang First People's Hospital
Suzhou, Jiangsu, China
Xuzhou Central Hospital
Xuzhou, Jiangsu, China
Ganzhou Cancer Hospital
Ganzhou, Jiangxi, China
Ganzhou People's Hospital
Ganzhou, Jiangxi, China
Jilin Cancer Hospital
Changchun, Jilin, China
The first hospital of Jilin University
Changchun, Jilin, China
Affiliated Zhongshan Hospital Of Dalian University
Dalian, Liaoning, China
Shengjing Hospital of China Medical University
Shenyang, Liaoning, China
Liaoning Cancer Hospital & Institute
Shenyang, Liaoning, China
People's Hospital of Ningxia Hui Autonomous Region
Yinchuan, Ningxia, China
Qinghai University Affiliated Hospital
Xining, Qinghai, China
Bao Ji Central Hospital
Baoji, Shaanxi, China
3201 Hospital
Hanzhong, Shaanxi, China
The Second Affiliated Hospital Of Xi'an Jiaotong University (Xibei Hospital)
Xi'an, Shaanxi, China
Xijing Hospital of Air Force Military Medical University
Xi'an, Shaanxi, China
Cancer Hospital of Shandong First Medical University (Shandong Cancer Institute,Shandong Cancer Hospital)
Jinan, Shandong, China
Linyi cancer Hospital
Linyi, Shandong, China
Weifang People'S Hospital
Weifang, Shandong, China
Shanxi Cancer Hospital
Taiyuan, Shanxi, China
Yuncheng Central Hospital
Yuncheng, Shanxi, China
Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital
Chengdu, Sichuan, China
The Affiliated Hospital of Southwest Medical University
Luzhou, Sichuan, China
Affiliated Hospital of North Sichuan Medical College
Nanchong, Sichuan, China
Suining Central Hospital
Suining, Sichuan, China
The Second People's Hospital of Yibin City
Yibin, Sichuan, China
Tianjin Medical University Cancer Institute & Hospital
Tianjin, Tianjin Municipality, China
Tianjin Cancer Hospital Airport Hospital
Tianjin, Tianjin Municipality, China
Xinjiang Medical University Affiliated Tumor Hospital
Ürümqi, Xinjiang, China
Yunnan Cancer Hospital
Kunming, Yunnan, China
Ningbo Medical Center Lihuili Hospital
Ningbo, Zhejiang, China
Ningbono.2Hospitai
Ningbo, Zhejiang, China
The First Affiliated Hospial of Ningbo University
Ningbo, Zhejiang, China
The Second Affiliated Hospital of Wenzhou Medical University
Wenzhou, Zhejiang, China