Clinical Research Directory

Inclusion Criteria: * Independent-living (ADL ≥5/6) * Men and women * Mobility impairment (5 Chair-rise test \>12 seconds) * Sedentarism (spend six or more hours per day sitting or lying down) * Positive screening for cognitive impairment according to the ICOPE screening tool with MMSE \[25-28\] * BMI ≥25 kg/m2 Exclusion Criteria: * Unintentional weight loss (≥10%) in past 6 months * Dementia * Life-threatening illnesses, with a life expectancy (judged by the investigating doctor) of less than 1 year * Severe cardiac disease, including NYHA Class III or IV congestive heart failure, clinically significant aortic stenosis, history of cardiac arrest, use of a cardiac defibrillator, or uncontrolled angina or any other contraindication to physical activity (as determined by a physician) or comorbid disease that would impair ability to participate in the ICOPE intense intervention such as renal failure on hemodialysis, severe psychiatric disorder (depressive participant will not be excluded) * Organizational inability (three-time per week during the 60 days) * Living in a Nursing-Home * Under legal protection measure (guardianship, curatorship, safeguard of justice