Clinical Research Directory

Inclusion Criteria: * Meet the diagnostic criteria for sarcopenia AWGS 2019 1. Grip strength less than 28.0 kg for males and less than 18.0 kg for females 2. 6-meter stride speed less than 1.0 m/s or 5-repetition sit-up test time ≥ 12 seconds or SPPB ≤ 9 points. 3. Bioelectrical Impedance Analysis (BIA) less than 7.0 kg/m² for males and 5.7 kg/m² for females or Dual-energy X-ray absorptiometry (DXA) less than 7.0 kg/m² for males and 5.4 kg/m² for females; * Age between 35-75 years old with high compliance; * Complete clinical data; * Voluntary participation in the program with informed consent and signing of the informed consent form. Exclusion Criteria: * A clear history of allergy to protein powder in the past 6 months, or the presence of diarrhea symptoms and the frequency of ≥ 7 days / month, the duration of more than 2 weeks; * Major physical diseases (diabetes with serious complications, malignant tumors, serious cardiovascular disease, neurological diseases or other diseases that may affect the effectiveness of exercise and nutritional interventions, etc.); * The past three months, new fractures and recently underwent joint replacement surgery patients; * Suffering from congenital bone or muscle diseases; * The simultaneous existence of other comorbidities affecting muscle metabolism, such as malignant tumors, liver disease, severe organ insufficiency such as nephrotic syndrome, renal failure and other diseases that may affect protein metabolism; * Participating in other clinical trials patients; * With sensory disabilities or other reasons significantly affecting the collection of data, such as severe deafness, blindness, mental disorders, etc.; * The researchers The researchers believe that other reasons are not suitable for clinical trials.