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Impact of Different CRRT Modalities, Dosing Strategies, and Timing on Kidney Recovery and Prolonged Kidney Dysfunction
Sponsor: Croatian Society for Organ Support
Summary
KARMA study is a hospital-based research study looking at how different ways of delivering kidney support therapy (CRRT) affect patients who are critically ill. In some cases, the kidneys may temporarily stop working in very sick patients, and machines are used to filter the blood. This study is exploring whether the way the investigators use these machines - how early to start, how much treatment to give, and what type to choose - makes a difference in how well the kidneys recover. By learning from many hospitals and hundreds of patients, KARMA hopes to improve treatment choices and help patients regain their kidney function faster.
Official title: A Multicentric Observational Study Examining How Different CRRT Modalities, Dosing Strategies, and Timing Impact Kidney Recovery and the Development of Prolonged Kidney Dysfunction (Acute Kidney Disease) in Critically Ill Patients
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
2500
Start Date
2025-09-25
Completion Date
2026-12-25
Last Updated
2025-07-04
Healthy Volunteers
No
Conditions
Interventions
Continuos renal replacement therapy
Different modalities of CRRT: continuous veno-venous hemofiltration; continuous veno-venous hemodialysis and continuous veno-venous hemodiafiltration Different doses of CRRT: low effluent dose (\<15 ml/kg/h); medium-low effluent dose (15-25 ml/kg/h); standard effluent dose (25-30 ml/kg/h); high effluent dose (\>30 ml/kg/h