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NOT YET RECRUITING
NCT07052760
EARLY_PHASE1

Imaging of Solid Tumors Using DLL3 SPECT

Sponsor: Thomas Hope

View on ClinicalTrials.gov

Summary

This is a single arm, pilot trial that evaluates the ability of a novel imaging agent (111In-ABD147) to detect metastatic cancer in participants with solid tumors. 111In-ABD147 is a high affinity Delta-like ligand 3 (DLL3) antigen binding domain fused to an engineered humanized Fc to create an antibody (VHH-Fc) that is bio-conjugated with a DOTA linker-chelator to a 111In radiometal. DLL3 is expressed on a variety of tumors, particularly those with neuroendocrine features.

Key Details

Gender

All

Age Range

18 Years - Any

Study Type

INTERVENTIONAL

Enrollment

45

Start Date

2025-11-30

Completion Date

2027-12-31

Last Updated

2025-10-10

Healthy Volunteers

No

Interventions

DRUG

111In-ABD147

Given intravenously (IV) prior to imaging

PROCEDURE

Single-photon emission computed tomography (SPECT)/Computerized tomography (CT)

Undergo imaging

Locations (1)

University of California, San Francisco

San Francisco, California, United States