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Imaging of Solid Tumors Using DLL3 SPECT
Sponsor: Thomas Hope
Summary
This is a single arm, pilot trial that evaluates the ability of a novel imaging agent (111In-ABD147) to detect metastatic cancer in participants with solid tumors. 111In-ABD147 is a high affinity Delta-like ligand 3 (DLL3) antigen binding domain fused to an engineered humanized Fc to create an antibody (VHH-Fc) that is bio-conjugated with a DOTA linker-chelator to a 111In radiometal. DLL3 is expressed on a variety of tumors, particularly those with neuroendocrine features.
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
45
Start Date
2025-11-30
Completion Date
2027-12-31
Last Updated
2025-10-10
Healthy Volunteers
No
Conditions
Interventions
111In-ABD147
Given intravenously (IV) prior to imaging
Single-photon emission computed tomography (SPECT)/Computerized tomography (CT)
Undergo imaging
Locations (1)
University of California, San Francisco
San Francisco, California, United States