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IV Dexamethasone in Preventing Post Spinal Hypotension
Sponsor: Pakistan Institute of Medical Sciences
Summary
Orthopedic lower limb procedures are carried out under spinal anesthesia which involves administration of drugs in the space surrounding the spinal cord. From there the drug acts on the spinal cord blocking electrical signals moving across nerve fibers thereby providing sufficient pain relief and surgical conditions. However blocking of these fibers result in reduce signal transmission to blood vessels and heart resulting in fall in blood pressure. Various drugs can be used to treat or prevent this hypotension. One such drug is Dexamethasone which is a steroid. This drug can be administered before spinal anesthesia through Intravenous route to prevent fall in blood pressure.
Official title: Efficacy of Dexamethasone in Preventing Postspinal Hypotension in Elderly Patients Undergoing Orthopedic Surgery: a Randomized Controlled Study
Key Details
Gender
All
Age Range
50 Years - 100 Years
Study Type
INTERVENTIONAL
Enrollment
134
Start Date
2025-06-30
Completion Date
2025-08-05
Last Updated
2025-07-31
Healthy Volunteers
Yes
Conditions
Interventions
Dexamethasone
8 mg of Intravenous Dexamethasone in 100 ml Normal saline given 1 hour before anesthesia induction
Placebo
100ml of Normal saline administration 1 hour before anesthesia induction
Locations (1)
Deparment of Anesthesia and Critical Care Medicine, Pakistan Institute of Medical Sciences
Islamabad, Federal, Pakistan