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TRITON-CM: A Study to Evaluate Nucresiran in Patients With Transthyretin Amyloidosis With Cardiomyopathy
Sponsor: Alnylam Pharmaceuticals
Summary
The purpose of this study is to: * Evaluate the efficacy of nucresiran compared to placebo on reducing all-cause mortality and cardiovascular (CV) events * Evaluate the efficacy of nucresiran compared to placebo on additional assessments of CV events and/or death * Evaluate the efficacy of nucresiran compared to placebo on patient-reported health status and health-related quality of life
Official title: TRITON-CM: A Phase 3 Global, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Nucresiran in Patients With Transthyretin-Mediated Amyloidosis With Cardiomyopathy (ATTR Amyloidosis With Cardiomyopathy)
Key Details
Gender
All
Age Range
18 Years - 85 Years
Study Type
INTERVENTIONAL
Enrollment
1250
Start Date
2025-07-02
Completion Date
2032-11-30
Last Updated
2026-03-31
Healthy Volunteers
No
Interventions
Nucresiran
Nucresiran 300 mg administered SC q6M
Sterile Normal Saline (0.9% NaCl)
Sterile Normal Saline (0.9% NaCl) administered SC once q6M
Locations (157)
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La Jolla, California, United States
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Washington D.C., District of Columbia, United States
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Brandon, Florida, United States
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Atlanta, Georgia, United States
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Gainesville, Georgia, United States
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Tucker, Georgia, United States
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Indianapolis, Indiana, United States
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Indianapolis, Indiana, United States
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Kansas City, Kansas, United States
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Boston, Massachusetts, United States
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Detroit, Michigan, United States
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Rochester, Minnesota, United States
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St Louis, Missouri, United States
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Manhasset, New York, United States
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New York, New York, United States
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The Bronx, New York, United States
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Charlotte, North Carolina, United States
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Lancaster, Pennsylvania, United States
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Philadelphia, Pennsylvania, United States
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Dallas, Texas, United States
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Houston, Texas, United States
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Salt Lake City, Utah, United States
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Charlottesville, Virginia, United States
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Norfolk, Virginia, United States
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Spokane, Washington, United States
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Buenos Aires, Argentina
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Buenos Aires, Argentina
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Buenos Aires, Argentina
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Buenos Aires, Argentina
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Rosario, Argentina
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Bedford Park, Australia
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Box Hill, Australia
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Chermside, Australia
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Darlinghurst, Australia
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Joondalup, Australia
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Braunau am Inn, Austria
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Graz, Austria
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Wels, Austria
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Aalst, Belgium
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Brussels, Belgium
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Dendermonde, Belgium
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Ghent, Belgium
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Hasselt, Belgium
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Leuven, Belgium
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Liège, Belgium
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Roeselare, Belgium
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Belo Horizonte, Brazil
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Porto Alegre, Brazil
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Ribeirão Preto, Brazil
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São Paulo, Brazil
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London, Canada
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Aarhus N, Denmark
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København Ø, Denmark
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Odense C, Denmark
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Chambray-lès-Tours, France
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La Tronche, France
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Marseille, France
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Montpellier, France
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Paris, France
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Pessac, France
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Reims, France
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Rennes, France
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Rouen, France
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Saint-Herblain, France
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Toulouse, France
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Berlin, Germany
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Hanover, Germany
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Leipzig, Germany
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Munich, Germany
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Münster, Germany
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Würzburg, Germany
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Athens, Greece
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Athens, Greece
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Heraklion, Greece
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Thessaloniki, Greece
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Hong Kong, Hong Kong
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Be’er Ya‘aqov, Israel
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Haifa, Israel
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Jerusalem, Israel
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Petah Tikva, Israel
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Ancona, Italy
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Brescia, Italy
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Florence, Italy
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Forlì, Italy
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Naples, Italy
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Pavia, Italy
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Pisa, Italy
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Rimini, Italy
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Roma, Italy
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Bunkyō City, Japan
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Fukuoka, Japan
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Fukuoka, Japan
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Kagawa, Japan
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Kashihara, Japan
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Kobe, Japan
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Kumamoto, Japan
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Kurume, Japan
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Matsumoto-shi, Japan
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Nankoku, Japan
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Niigata, Japan
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Okayama, Japan
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Sapporo, Japan
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Sapporo, Japan
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Sendai, Japan
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Kajang, Malaysia
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Eindhoven, Netherlands
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Groningen, Netherlands
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Rotterdam, Netherlands
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Utrecht, Netherlands
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Christchurch, New Zealand
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Hamilton, New Zealand
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Carnaxide, Portugal
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Creixomil, Portugal
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Leiria, Portugal
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Lisbon, Portugal
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Lisbon, Portugal
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Vila Real, Portugal
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Viseu, Portugal
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Incheon, South Korea
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Seoul, South Korea
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Seoul, South Korea
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Seoul, South Korea
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Seoul, South Korea
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A Coruña, Spain
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Barcelona, Spain
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Barcelona, Spain
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Bilbao, Spain
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El Palmar, Spain
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Huelva, Spain
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Jaén, Spain
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L'Hospitalet de Llobregat, Spain
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Lleida, Spain
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Madrid, Spain
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Madrid, Spain
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Palma de Mallorca, Spain
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Pamplona, Spain
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Salamanca, Spain
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Santiago de Compostela, Spain
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Valencia, Spain
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Valencia, Spain
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Vigo, Spain
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Gothenburg, Sweden
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Lund, Sweden
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Solna, Sweden
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Basel, Switzerland
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Genève, Switzerland
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Lucerne, Switzerland
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Sankt Gallen, Switzerland
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New Taipei City, Taiwan
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Taipei, Taiwan
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Taipei, Taiwan
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Bellshill, United Kingdom
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Birmingham, United Kingdom
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Cardiff, United Kingdom
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London, United Kingdom
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London, United Kingdom
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Manchester, United Kingdom