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UPBEAT: Using Polygenic Scores to Guide BB Therapy in HF With Mildly Reduced EF
Sponsor: David Lanfear
Summary
This study will use polygenic scores, a tool which describes differences in genetics, to examine effectiveness of beta blocker medication in heart failure patients with ejection fraction of 41-50 percent. The study will also assess beta blockers' effect on the changes in left ventricular end-systolic volume index by MRI.
Official title: Using Polygenic Scores to Guide Beta-blocker Therapy for Heart Failure With Mildly Reduced Ejection Fraction
Key Details
Gender
All
Age Range
18 Years - 89 Years
Study Type
INTERVENTIONAL
Enrollment
10
Start Date
2025-11
Completion Date
2026-11
Last Updated
2025-11-10
Healthy Volunteers
No
Conditions
Interventions
Beta blocker
Participants randomized to intervention will be dosed and titrated on beta blocker according to study protocol.
Locations (1)
Henry Ford Health
Detroit, Michigan, United States