Clinical Research Directory
Browse clinical research sites, groups, and studies.
Effect of Metformin as Add-on Therapy in Levodopa Treated Parkinson's Disease Patients
Sponsor: Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
Summary
The goal of this clinical trial is to learn that metformin has effect on motor aspects of daily living and oxidative stress in levodopa treated Parkinson disease patients. Researcher will compare drug metformin to a placebo. Participants will take metformin or placebo for 8 weeks.
Official title: Effect of Metformin as Add-on Therapy in Levodopa Treated Parkinson's Disease Patients: Randomized, Double Blind, Placebo Controlled Trial
Key Details
Gender
All
Age Range
Any - Any
Study Type
INTERVENTIONAL
Enrollment
74
Start Date
2024-12-29
Completion Date
2025-07-20
Last Updated
2025-07-09
Healthy Volunteers
No
Conditions
Interventions
Metformin
Metformin's chemical name is 1,1-Dimethylbiguanide, a molecular formula of C4H11N5. Beyond its well established antihyperglycemic impact, metformin demonstrated anti-oxidant and anti-inflammatory activities contributing its potential benefits in conditions associated with inflammation and oxidative stress. Furthermore, metformin rapidly crosses the blood brain barrier and disperses into several brain regions presenting an ideal therapeutic option for the treatment of PD.
placebo
placebo of tab. Metformin of same shape
Locations (1)
BSMMU
Dhaka, Bangladesh