Clinical Research Directory

Inclusion Criteria: * Men and women between 30 and 60 years old. * Diagnosis of Metabolic Syndrome (MS) according to the International Diabetes Federation (IDF) criteria. Waist circumference ≥90 cm in men and ≥80 cm in women, plus the presence of two or more of the following criteria: * Fasting glucose ≥100 mg/dL or previous diagnosis of type 2 diabetes. * Systolic Blood Pressure ≥130 mmHg. * Diastolic Blood Pressure ≥85 mmHg. * Triglycerides ≥150 mg/dL. * HDL cholesterol \<40 mg/dL in men and \<50 mg/dL in women. * Body Mass Index between 25.0 and 34.9 kg/m². * Stable weight during the 3 months prior to the start of the study (weight variation less than 10%). * Not receiving pharmacological treatment for any component of MS, insulin sensitivity, and/or insulin secretion. * Signed informed consent form. Non-Inclusion Criteria: * Suspected or confirmed pregnancy. * Breastfeeding period. * Fasting glucose ≥126 mg/dL. * LDL cholesterol ≥155 mg/dL. * Triglycerides ≥500 mg/dL. * Systolic blood pressure ≥140 mmHg and diastolic blood pressure ≥90 mmHg. * Use of medications and/or supplements known to influence the study variables. * History of kidney, thyroid, liver disease, or ischemic heart disease. * Active smoker. * Not using an effective and stable contraceptive method. Exclusion Criteria: * Voluntary withdrawal of informed consent. * Treatment adherence ≤80%. * Occurrence of a serious adverse event. * Loss to follow-up.