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Comparison of the Outcome of Treatment With Silymarin or N-Aceylcysteine in Patients Taking Anti-Tuberculous Drugs for Tuberculosis at a Tertiary Care Hospital , Karachi
Sponsor: Liaquat National Hospital & Medical College
Summary
OBJECTIVE : To compare the outcome of treatment with silymarin or N-acetyl cysteine in patients taking anti-tuberculous drugs for tuberculosis at Tertiary Care Hospital, Karachi. SAMPLE SELECTION : Patients presenting with tuberculosis previously not on anti-tuberculous drugs, between 40-80 years of age, both genders will be included .Patients with history of alcohol use,Discontinuation of drug due to other adverse effects except hepatotoxicity ,Inadequate date of laboratory testing at baseline or 2 to 4 weeks after treatment initiation, Cases with human immunodeficiency virus (HIV) co-infection, viral hepatitis, or suspected mal absorption (e.g., gastrointestinal disease or diarrhea) ,Chronic liver disease, COPD, asthma, myocardial infarction, chronic kidney disease and stroke will be excluded
Key Details
Gender
All
Age Range
40 Years - 80 Years
Study Type
INTERVENTIONAL
Enrollment
410
Start Date
2025-07
Completion Date
2026-05
Last Updated
2025-07-10
Healthy Volunteers
No
Interventions
Silymarin 420 mg
silymarin group received silymarin 140mg thrice daily along with antituberculous drugs for 14 days
N Acetyl Cysteine
N- acetylcysteine group will receive N-acetylcysteine 900mg once daily with antituberculous drugs for 14 days
Rifampicin (RMP) Ethambutol (E) Isoniazid (H) Pyrazinamid (Z)
Antituberculous drugs only