Clinical Research Directory

Inclusion Criteria: * Age ≥ 18 years * Indication for prosthetic revision (PTG, PUC, PTH or hip hemiarthroplasty, PTE) or internal osteosynthesis with suspicion of IOAM following the opinion of a Réunion de concertation Pluridisciplinaire (RCP) on complex osteoarticular infections * Normal CPK level according to laboratory standard * Social security affiliation * Signature of informed consent * Negative pregnancy test for women of childbearing age. Exclusion Criteria: * Antibiotic therapy in the 3 months prior to inclusion * Clinical or radiological signs making HAI highly probable: scar discharge and/or peri-scar cellulitis fistula or abscess, bacteremia * positive bacterial culture from joint puncture or biopsy prior to revision * Chronic inflammatory bowel disease. * Previous surgical resection of small intestine or colon. * Hypersensitivity to daptomycin or any of its excipients. * Hypersensitivity to cefepime or any of its excipients or to other beta-lactamins. * Hypersensitivity to piperacillin+tazobactam or to any of the excipients or to other beta-lactamines. * Hypersensitivity to ceftobiprole or to any of the excipients or to other beta-lactamines. * Renal insufficiency with GFR \< 50ml/min/1.73 m2 (CKD-EPI). * Treatment with bosentan. * Treatment with probenecid. * Pre-existing seizure disorder. * Contraindication to L-arginine, acidosis, hyperkalemia that cannot be corrected. * Treatment with HMG-CoA reductase inhibitors. * Treatment with statins (pitavastin, pravastatin, rosuvastatin) or glyburide. * Patients in a medical emergency. * Pregnant or breast-feeding women. * Patient participating in another ongoing trial. * Mental state rendering the patient incapable of understanding this research. * Patient deprived of liberty by administrative or judicial decision.