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Screening for Anal Cancer and Precancer in Women With HIV (SANCA)
Sponsor: Karolinska Institutet
Summary
The main aim of the SANCA study is to evaluate the feasibility, cost-effectiveness, and acceptability of implementing international anal cancer screening guidelines for women living with HIV in Sweden, integrating health economic and patient-centered approaches. Secondly the investigators wish to investigate the predictive potential of DNA methylation markers for the clinical progression of precancerous anal lesions in women with HIV, combining prospective molecular biology analysis with clinical data from registries.
Key Details
Gender
FEMALE
Age Range
45 Years - Any
Study Type
INTERVENTIONAL
Enrollment
1000
Start Date
2025-09-01
Completion Date
2035-12-31
Last Updated
2025-07-10
Healthy Volunteers
No
Conditions
Interventions
anal HPV screening
From all included women samples will be collected at the out-patient HIV departments including self-sampled vaginal swab for hrHPV testing and self-sampled anal swab for hrHPV. A blood sample will be taken for the analysis of circulating HPV DNA.
Locations (1)
Karolinska Institutet
Stockholm, Sweden