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Endogenous Energy Production in Critically Ill Patients
Sponsor: Karolinska University Hospital
Summary
The aim of this study is to investigate when critically ill patients transition from a non-suppressible catabolism to a normal response to feeding. Endogenous production of glucose, fat and protein will be studied on a minimum of two occasions in mechanically ventilated ICU patients, in a fasted state and during parenteral nutrition. Substrate kinetics are estimated by a tracer dilution method using infusions of isotopically labeled glucose, glycerol and phenylalanine. Blood sampling for metabolomics analysis will be performed to elucidate potential biomarkers indicating an anabolic response to nutrition.
Official title: The Effect of Nutrition on Endogenous Energy Substrate Production in the Early and Late Acute Phase of Critical Illness
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
40
Start Date
2025-07
Completion Date
2027-05
Last Updated
2025-07-11
Healthy Volunteers
Yes
Interventions
Stable isotope tracers
Deuterium-labelled non-radioactive stable isotopes of glucose, phenylalanine and glycerol.
Parenteral nutrition
Parenteral nutrition infused a rate corresponding to 100% of measured energy expenditure, started after blood sampling during a baseline fasting period.
Locations (1)
Karolinska University Hospital Huddinge
Stockholm, Sweden