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sTMS Combined With CIMT and taVNS In Infants With Hemiplegia
Sponsor: Medical University of South Carolina
Summary
Preterm and term infants with brain injury frequently have delayed motor skills, and one hand and arm may become stronger than the other, which can signal early cerebral palsy. A new treatment, transcutaneous vagus nerve stimulation (taVNS), boosts specific brain circuits and may improve function when paired with intensive motor activities. This study will test taVNS-paired constraint induced movement therapy in infants who have greater weakness on one side and determine if a single pulse of transcranial brain stimulation over the motor area can cause a measurable movement of the hand or thumb, and indicate which infants can benefit from 40h taVNS-paired CIMT.
Official title: Integrating Corticospinal Tract Assessment Via sTMS And taVNS-Augmented CIMT In Infants With Hemiplegia
Key Details
Gender
All
Age Range
8 Months - 24 Months
Study Type
INTERVENTIONAL
Enrollment
10
Start Date
2025-11-07
Completion Date
2026-12-31
Last Updated
2025-11-26
Healthy Volunteers
No
Conditions
Interventions
sTMS
Single pulses of TMS will be delivered over the motor cortex to quantify and map the motor evoked potentials
taVNS
taVNS will be used to stimulate the auricular branch of the vagus nerve and paired with CIMT for a total of 40hours of CIMT
Locations (1)
Medical University of South Carolina
Charleston, South Carolina, United States