Clinical Research Directory

Browse clinical research sites, groups, and studies.

Sites Groups Studies

Back to Studies

RECRUITING

NCT07065461

The Chocolate Almond Study - Relating Chewing to Satiation and Postprandial Response

Sponsor: University of Guelph

View on ClinicalTrials.gov

Summary

The goal of this clinical trial is to relate chewing behaviours to food intake and postprandial response for a texturally complex food matrix (almonds in white chocolate) in healthy young females. The main questions it aims to answer are: * Does the presence or preparation of almonds (whole versus chopped) influence satiation, i.e., the amount consumed at an ad libitum meal? * What is the correlation between chewing behaviour, satiation, and changes in postprandial glucose, triacylglycerols, and satiety ratings? Participants will attend the research centre fasted on three occasions to consume an ad libitum meal, complete questionnaires, and provide fasting and postprandial finger prick blood samples.

Official title: The Impact of Almond Size in a White Chocolate Matrix on Satiation, Postprandial Glycemia & Lipemia, Chewing Exertion, Eating Rate, and Product Liking: A Randomized Crossover Trial

Key Details

Gender

FEMALE

Age Range

18 Years - 45 Years

Study Type

INTERVENTIONAL

Enrollment

Start Date

2025-06-01

Completion Date

2026-05

Last Updated

2025-07-15

Healthy Volunteers

Yes

Conditions

Satiation, Satiety Postprandial Glycemia Postprandial Lipemia

Interventions

OTHER

200 g serving of white chocolate-based confection product

Inclusion Criteria: * BMI between 18.5-27.9 kg/m\^2 or waist circumference less than 88 cm * No known food allergies or sensitivities * Non-restrained eaters based on the Three Factor Eating Questionnaire * No history of gastrointestinal diseases that may interfere with eating behaviour or digestion * Not on medications that affect appetite, digestion, blood sugar regulation, saliva production, or chewing * Stable medication use * Non-smokers * Not gained or lost significant weight during the past 3 months * Regular monthly menstrual cycles * Not pregnant, lactating, or post-menopausal Exclusion Criteria: * Diabetes or other metabolic disorders affecting glycemia and overall cardiometabolic health * Any food allergies, intolerance, or sensitivities * Any life-threatening allergy * Pregnant or breastfeeding * Participation in another clinical trial * Alcohol consumption more than 14 drinks per week * Smokers or those with a smoking history or more than 10 years * Regular use of recreational drugs (e.g., marijuana, ecstasy, magic mushrooms) * Restrained eater as defined by \> 15 on the Three-Factor Eating Questionnaire * Unusual sleep patterns * Irregular breakfast consumption * Recent weight changes or intended weight loss or gain or having lost or gained \>10% of body weight within the last 6 months * Using medications known to affect appetite, digestion, blood sugar regulation, lipids, or chewing (excluding oral contraceptives) * Experiences dry mouth, in general or due to medication side effects * Diagnosed with Sjogren's Syndrome (autoimmune condition linked to severe dry mouth) * Inability to adhere to study protocols * Not comfortable providing finger prick blood samples * Avoids consuming almonds or chocolate * Has temporomandibular joint disorder (TMJ) * Has or history or oral cancer * Recent dental or jaw surgery * Avoids eating hard foods for concerns of dental fractures or for general oral health * Individuals with dentures, braces, Invisalign, or other dental implants that cause difficulty chewing

Locations (1)

Department of Human Health Sciences

Guelph, Ontario, Canada