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The Effect of Asymmetrical vs. Symmetrical High Flow Nasal Cannula on the Work of Breathing
Sponsor: Larissa University Hospital
Summary
The goal of this study randomized single-center crossover study is to evaluate the impact of asymmetrical versus symmetrical nasal high flow (NHF) therapy on work of breathing (WOB). The main question it aims to answer are: 1\. Does the asymmetrical NHF interface improve the work of breathing compared to the symmetrical NHF interface? Researchers will compare the symmetrical NHF interface to the symmetrical NHF interface to see if the the asymmetrical interface has a greater impact on the work of breathing. Participants will : 1. receive NHF via both interfaces (FiO₂ 0.21, 50 L/min) for 15 minutes, in random order, with esophageal pressure monitoring and bioelectrical impedance analysis performed. 2. baseline characteristics will me monitored throughout the interventions 3. Esophageal pressure and minute ventilation will be monitored.
Official title: The Effect of Asymmetrical vs. Symmetrical High Flow Nasal Cannula on the Work of Breathing: A Randomised Cross-over Study
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
30
Start Date
2024-04-09
Completion Date
2025-09-01
Last Updated
2025-07-18
Healthy Volunteers
Yes
Conditions
Interventions
Asymmetric nasal cannula - DUET
DUET asymmetric nasal high flow interface that fits best to patients' nostrils (size: one nostril of the patient should be fully occluded) Patients will be crossed - over between the 2 interventions
Conventional nasal high flow cannula
Well - established conventional nasal high flow cannula (size: medium) Patients will be cross - over between the 2 interventions
Locations (1)
University Hospital of Larissa, Department of Pulmonary Medicine
Larissa, Greece