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Quantification of Mitral Regurgitation Using 4D MRI Flow : Comparison With 2D MRI Flow and Echocardiography Using the Evolution of Left Ventricular Remodeling as a Reference
Sponsor: Assistance Publique - Hôpitaux de Paris
Summary
The goal of this study is to evaluate whether 4D MRI provides a better assessment of mitral regurgitation quantification and associated ventricular remodeling than standard imaging techniques: echocardiography and 2D MRI, in patients suffuring from mitral regurgitation. 4D MRI demonstrated its superiority to 2D MRI in some other valve diseases but remains not widely used, due to a lack of evidence. The main question our study aims to answer is: • Is mitral regurgitant volume measured on 4D MRI more strongly related to remodeling progression (after correction of regurgitation or not) than regurgitant volume measured on 2D MRI and echocardiography? Participants will undergo 4D MRI, 2D MRI and echocardiography twice at six-month intervals.
Key Details
Gender
All
Age Range
18 Years - 85 Years
Study Type
INTERVENTIONAL
Enrollment
160
Start Date
2025-10-01
Completion Date
2028-04-30
Last Updated
2025-07-15
Healthy Volunteers
No
Conditions
Interventions
Standard echocardiography
Routine ultrasound examination with standardized recordings for the study, incorporating volumetric assessment techniques
2D phase-contrast magnetic resonance imaging
A cardiac MRI will be performed on a 1.5 Tesla system, including a biventricular function study with a series of short-axis slices, three long-axis slices, a 2D phase-contrast acquisition orthogonal to the aortic root. Additionally, standard T1 mapping sequences will be acquired on three short-axis slices, 15 minutes after the injection of 0.2 mmol/kg of body weight of gadolinium, for myocardial and blood T1 measurements.
4D flow magnetic resonance imaging
A sagittal 4D flow acquisition lasting between 6 and 10 minutes of free breathing to cover all four cardiac chambers is added to the 2D acquisition.
Cardiac ultrafast ultrasound imaging
Ultrafast sequences are added to the standard echocardiography acquisition.
Locations (3)
Groupe hospitalier Paris Saint-Joseph - hôpital Marie-Lannelongue
Le Plessis-Robinson, France
AP-HP - hôpital Saint-Antoine
Paris, France
AP-HP - hôpital européen Georges-Pompidou,
Paris, France