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LTV (Low Tidal Volüme) Ventilation and Diaphragmatic Motion in CABG (Coronary Artery Bypass Grafting)
Sponsor: Konya City Hospital
Summary
The goal of this clinical trial is to evaluate whether low tidal volume (LTV) ventilation during cardiopulmonary bypass (CPB) surgery helps preserve diaphragmatic excursion in adult patients undergoing coronary artery bypass grafting (CABG). The study will also assess the relationship between LTV ventilation and postoperative pulmonary complications, such as atelectasis, pleural effusion, and pneumonia. The main questions this trial aims to answer are: Does LTV ventilation better preserve diaphragmatic motion compared to apnea during CPB? Are postoperative pulmonary complications less frequent in patients receiving LTV? Does LTV contribute to shorter extubation times and ICU stays? Researchers will compare LTV ventilation with apnea (standard care) during CPB to assess its effects on diaphragmatic excursion, measured via ultrasound, and postoperative respiratory outcomes. Participants will: Undergo elective CABG surgery under general anesthesia Be randomly assigned to receive either LTV ventilation or apnea during CPB Have diaphragmatic excursion measured by ultrasound before surgery, before extubation, and 24 hours after surgery Be monitored for postoperative pulmonary complications (atelectasis, effusion, pneumonia), extubation time, and ICU length of stay Ultrasound will be used to measure diaphragmatic excursion (DE) in quiet and deep breathing. DE below 10 mm will be considered as diaphragmatic paralysis. Postoperative respiratory assessments will include blood gas analysis (PaO₂/FiO₂ ratio), clinical respiratory parameters, and imaging findings. This is a prospective, single-center, assessor-blinded randomized controlled trial. Patients and outcome assessors will be blinded to group allocation. The study will be conducted at the Anesthesiology Clinic of Konya City Hospital and is expected to enroll 60 patients.
Official title: The Effect of Low Tidal Volume Ventilation on Diaphragmatic Excursion in Cardiopulmonary Bypass Surgery
Key Details
Gender
All
Age Range
18 Years - 75 Years
Study Type
INTERVENTIONAL
Enrollment
60
Start Date
2025-07-01
Completion Date
2025-11-30
Last Updated
2026-09-15
Healthy Volunteers
No
Interventions
Low Tidal Volume Ventilation During CPB
Group Low: Patients in this group will receive low tidal volume mechanical ventilation during cardiopulmonary bypass (CPB). Ventilation settings will be: Tidal Volume: 3-4 mL/kg (ideal body weight) PEEP: 5-8 cmH₂O Respiratory Rate: adjusted to maintain normocapnia (PaCO₂ 35-45 mmHg)
Locations (1)
Konya City Hospital
Konya, Konya, Turkey (Türkiye)