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Weaning Approaches for Vasopressin in Sepsis
Sponsor: Hospital Nossa Senhora da Conceicao
Summary
In this study, we aim to evaluate the incidence of hypotension during vasopressin weaning by comparing two methods - titrated reduction versus abrupt withdrawal - through the conduct of a randomized clinical trial.
Official title: Weaning Approaches for Vasopressin in Sepsis - a Randomized Controlled Trial of Titrated Versus Abrupt Discontinuation During Stabilization of Septic Shock - WAVES Trial
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
82
Start Date
2025-10-01
Completion Date
2028-10-01
Last Updated
2026-01-02
Healthy Volunteers
No
Conditions
Interventions
Titrated weaning of vasopressin.
The titrated group will follow the vasopressin weaning protocol used in the DOVSS study (reduction of 0.01 U/min per hour).
Abrupt weaning of vasopressin.
The abrupt group will discontinue the vasopressin infusion at the time of randomization, without dose titration.
Locations (1)
Hospital Nossa Senhora da Conceição
Porto Alegre, Rio Grande do Sul, Brazil