Clinical Research Directory

Inclusion Criteria: 1. Meeting the diagnostic criteria for migraine without aura (MwoA) according to the International Classification of Headache Disorders, 3rd edition (ICHD-3) ; 2. Aged 18-65 years; 3. A history of migraine for at least 1 year; 4. At least 2 migraine attacks per month; 5. No prophylactic medications or other treatments for migraine within the past month; 6. Visual Analog Scale (VAS) score \> 3; 7. Willing and capable of providing written informed consent. Exclusion Criteria: 1. Diagnosed with other primary headaches such as neuropathic headache, cluster headache, or tension-type headache; 2. Comorbid secondary headaches or other neurological disorders (e.g., headache due to anxiety, depression, Parkinson's disease, or intracranial lesions); 3. Uncontrolled or undiagnosed systemic diseases that may interfere with the study, including severe hepatic, renal, cardiovascular, or cerebrovascular diseases; poorly controlled or untreated hypertension (systolic blood pressure \> 160 mmHg and/or diastolic blood pressure \> 100 mmHg); poorly controlled or untreated diabetes mellitus; malnutrition; hyperthyroidism; or hepatic insufficiency; 4. Comorbid uncontrolled psychiatric disorders; 5. Pregnancy, lactation, or women in the preparation, menstrual, or menopausal phase; 6. Use of prophylactic medications or other treatments for migraine within the past month; 7. History of allergy to the trial medications or contraindications to flunarizine hydrochloride or ibuprofen; 8. Skin lesions at the FSN operation site; 9. Occupations involving driving, working at heights, or other high-risk activities; 10. Refusal to undergo FSN therapy or oral flunarizine hydrochloride.