Clinical Research Directory
Browse clinical research sites, groups, and studies.
Small Extracellular Vesicle miRNAs as Predictive Biomarkers for Immunochemotherapy Efficacy in Extensive-stage Small Cell Lung Cancer
Sponsor: Shanghai Chest Hospital of Shanghai Jiao Tong University
Summary
This study aims to investigate the clinical value of small extracellular vesicle (sEV) miRNAs as predictive biomarkers for immunochemotherapy efficacy in extensive-stage small cell lung cancer (ES-SCLC). ES-SCLC represents a highly aggressive neuroendocrine malignancy, where the current standard first-line treatment combining immune checkpoint inhibitors with chemotherapy lacks predictive biomarkers for individualized therapeutic strategies. A prospective observational cohort will be established at Shanghai Chest Hospital, enrolling treatment-naïve ES-SCLC patients. Distinct miRNA signatures differentiating responders from non-responders will be identified through pretreatment serum sEV miRNA sequencing and differential expression analysis. These findings may provide novel liquid biopsy biomarkers to guide personalized treatment strategies and optimize clinical decision-making in ES-SCLC management.
Key Details
Gender
All
Age Range
45 Years - 80 Years
Study Type
OBSERVATIONAL
Enrollment
38
Start Date
2023-01-03
Completion Date
2026-12-31
Last Updated
2025-07-17
Healthy Volunteers
No
Interventions
EC/EP + ICIs
Collect blood samples from patients with small cell lung cancer before receiving immunotherapy combined with chemotherapy.
Locations (1)
Shanghai Chest Hospital
Shanghai, China